Evaluation of anti tumour activity of ethanolic extract of beet root (Beta vulgaris) against EAC mouse tumor model

P. Kumar, A. Bhaumik, D. B. Rao, M. Chopra
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Abstract

Introduction: EAC is referred to as undifferentiated carcinoma, and is originally hyper-diploid. The permeability to water is highest at the initiation of S and progressively decreases to its lowest value just after mitosis. Activation heats for water permeability vary during the cell cycle, ranging from 914 k. ca/mole. Methodology: The extraction of phytoconstituents was carried out by reflux condensation and preliminary phytochemical screening was done by various qualitative confirmatory tests. The in vivo anti tumour activity of ethanolic extract of beet root (EEBT) was carried out on EAC mouse tumour models. Results: All five animals were in both 5-FU as well as EEBT group. So mortality was less in both 5-FU and EEBT group. The Hb and RBC count were lower in tumour control group. The WBC counts were significantly increased in tumour control. 5-FU and EEBT mg/kg group decreased the WBC counts approximately near to normal range. The neutrophils were increased and lymphocytes were decreased significantly in tumour control group. The platelet count was also significantly increased in tumour control and EEBT (200 mg/kg) group compared nearly to normal group. EEBT and 5-FU significantly increased the PILS. While 5-FU increased the life span of EAC 90.90% and EEBT increased the life span of EAC 86.36%. Conclusion: From the present experimental data here we concluded that the EEBT possessed potential anti tumour activity against EAC mouse tumour model which was proved by the assessment of haematological parameters as well as by Percent increase of lifespan (% ILS). The Percent increase of lifespan ( PILS) of both standard group as well as EEBT treated group was found to be 90.90% and 86.36%.
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甜菜根乙醇提取物对EAC小鼠肿瘤模型的抗肿瘤活性评价
EAC被称为未分化癌,最初是超二倍体。对水的渗透性在S起始时最高,在有丝分裂后逐渐降低至最低。水渗透的活化热在细胞周期中变化,范围从914千卡/摩尔。方法:采用回流冷凝法提取植物成分,并通过各种定性验证试验进行初步的植物化学筛选。在EAC小鼠肿瘤模型上进行了甜菜根乙醇提取物(ebt)的体内抗肿瘤活性研究。结果:5只动物均为5-FU组和EEBT组。因此,5-FU组和EEBT组的死亡率都较低。肿瘤对照组Hb和RBC计数较低。肿瘤对照组WBC计数明显增加。5-FU和EEBT mg/kg组白细胞计数下降接近正常范围。肿瘤对照组中性粒细胞明显增加,淋巴细胞明显减少。与正常组相比,肿瘤对照组和EEBT (200 mg/kg)组血小板计数也显著增加。ebt和5-FU显著提高了PILS。5-FU延长EAC寿命90.90%,ebt延长EAC寿命86.36%。结论:从目前的实验数据来看,ebt对EAC小鼠肿瘤模型具有潜在的抗肿瘤活性,这一点通过血液学指标的评估和寿命百分比(% ILS)的增加得到了证实。标准组和EEBT治疗组的寿命延长率分别为90.90%和86.36%。
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