{"title":"INCREASED EXPRESSION OF p62~(pan-myc) IN GASTRIC PYLORI MUCOSA BIOPSIES FROM SUBJECTS EXPOSED TO N-NITROSAMIDES","authors":"D. Daju","doi":"10.1097/00008469-199609001-00042","DOIUrl":null,"url":null,"abstract":"To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.","PeriodicalId":22576,"journal":{"name":"The Journal of Beijing Medical University","volume":"1 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"The Journal of Beijing Medical University","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/00008469-199609001-00042","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
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Abstract
To elucidate the possible role of myc oncogene in human gastric carcinogenesis byN-nitrosamides Methods: Expression of pan-myc in gastric biopsies of pylori and concentration of totalN-nitrosamides in fasting gastric juice samples were studied simultaneously with immunochemohistological method and liquid mobile-photohydrolysis-pyrolysis energy analyzer. Results: Ofgastric juice samples, 57. 1 % were N-nitrosamide-detectable. Evaluation of p62pan-myc in mucosal epithelial cells Was found in 6 gastric biopsies. All the 6 p62pan-myc-positive biopsies were from patients whosegastric juices were N-nitrosamide-detectable, whereas no p62 pan-myc-positive biopsy was found inthose from 15 cases whose gastric juices were N-nitrosamide-undetectab1e (P= 0. 0239). Such relationwas not observed for p21pan-ras, p185c-erbB-2, and p53mutant p53. Conclusion: These results indicate firstlythat expression of myc oncogene correlated with the exposure to N-nitrosamides in human stomach positively and myc oncogene may play a role in the early stage of human gastric carcinogenesis by N-nitrosamides.
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