Oxidative stress, antioxidant defense and depressive disorders: A systematic review of biochemical and molecular markers

Q3 Medicine Neurology Psychiatry and Brain Research Pub Date : 2020-06-01 DOI:10.1016/j.npbr.2020.02.006

Maiza Lacerda Barbosa , Ag-Anne Pereira Melo de Meneses , Rai Pablo Sousa de Aguiar , João Marcelo de Castro e Sousa , Ana Amélia de Carvalho Melo Cavalcante , Sharbel Weidner Maluf

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引用次数: 27

Abstract

Background

Oxidative stress (OS) can contribute to the development of several diseases, including depressive disorders (DD). Antioxidant therapy been an important tool to depressive disorders or to side effects of the current therapy. This systematic review aimed to correlate the biochemical and molecular biomarkers of oxidative stress and antioxidant defenses with depressive disorders, through the evaluation of clinical studies.

Methods

The literature were obtained from the PubMed, Scielo, VHL, Medline and Scopus databases with the descriptors [depressive disorders], [vitamin antioxidants], [vitamin C], [retinol palmitate], [vitamin A] and [depression], combined.

Results

Several biomarkers of oxidative damage that affect biomolecules such as DNA, RNA, proteins and lipids and antioxidant defense biomarkers were analyzed in 28 articles selected by the the inclusion criteria. The biomarkers found were 8-OHdG, 3-NT, PCC, F2-Iso, 4-HNE, 8-Iso, MDA, SOD, CAT, GPx and vitamins A and C.

Conclusions

Most of the studies found significant associations between these biomarkers, depressive disorders. Thus, there are many perspectives for further studies that can clarify the relation of these biomarkers with depressive disorders.

Limitations

The scarce literature that fit the inclusion criteria may have limited this review.

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氧化应激、抗氧化防御和抑郁症:生化和分子标记的系统综述

背景氧化应激(OS)可促进多种疾病的发展，包括抑郁症(DD)。抗氧化治疗是目前治疗抑郁症或其副作用的重要手段。本系统综述旨在通过对临床研究的评估，将氧化应激和抗氧化防御的生化和分子生物标志物与抑郁症联系起来。方法从PubMed、Scielo、VHL、Medline和Scopus数据库中获取文献，文献描述词为[抑郁症]、[维生素抗氧化剂]、[维生素C]、[视黄醇棕榈酸酯]、[维生素A]和[抑郁症]。结果根据纳入标准选取了28篇文献，分析了几种影响DNA、RNA、蛋白质、脂质等生物分子的氧化损伤生物标志物和抗氧化防御生物标志物。发现的生物标志物有8-OHdG、3-NT、PCC、F2-Iso、4-HNE、8-Iso、MDA、SOD、CAT、GPx和维生素A和c。结论大多数研究发现这些生物标志物与抑郁症之间存在显著相关性。因此，有许多进一步的研究可以阐明这些生物标志物与抑郁症的关系。局限性:符合纳入标准的文献稀少可能限制了本综述。

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来源期刊

Neurology Psychiatry and Brain Research 医学-精神病学

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期刊介绍： Neurology, Psychiatry & Brain Research publishes original papers and reviews in biological psychiatry, brain research, neurology, neuropsychiatry, neuropsychoimmunology, psychopathology, psychotherapy. The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version. Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.