Maiza Lacerda Barbosa , Ag-Anne Pereira Melo de Meneses , Rai Pablo Sousa de Aguiar , João Marcelo de Castro e Sousa , Ana Amélia de Carvalho Melo Cavalcante , Sharbel Weidner Maluf
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引用次数: 27
Abstract
Background
Oxidative stress (OS) can contribute to the development of several diseases, including depressive disorders (DD). Antioxidant therapy been an important tool to depressive disorders or to side effects of the current therapy. This systematic review aimed to correlate the biochemical and molecular biomarkers of oxidative stress and antioxidant defenses with depressive disorders, through the evaluation of clinical studies.
Methods
The literature were obtained from the PubMed, Scielo, VHL, Medline and Scopus databases with the descriptors [depressive disorders], [vitamin antioxidants], [vitamin C], [retinol palmitate], [vitamin A] and [depression], combined.
Results
Several biomarkers of oxidative damage that affect biomolecules such as DNA, RNA, proteins and lipids and antioxidant defense biomarkers were analyzed in 28 articles selected by the the inclusion criteria. The biomarkers found were 8-OHdG, 3-NT, PCC, F2-Iso, 4-HNE, 8-Iso, MDA, SOD, CAT, GPx and vitamins A and C.
Conclusions
Most of the studies found significant associations between these biomarkers, depressive disorders. Thus, there are many perspectives for further studies that can clarify the relation of these biomarkers with depressive disorders.
Limitations
The scarce literature that fit the inclusion criteria may have limited this review.
期刊介绍：
Neurology, Psychiatry & Brain Research publishes original papers and reviews in
biological psychiatry,
brain research,
neurology,
neuropsychiatry,
neuropsychoimmunology,
psychopathology,
psychotherapy.
The journal has a focus on international and interdisciplinary basic research with clinical relevance. Translational research is particularly appreciated. Authors are allowed to submit their manuscript in their native language as supplemental data to the English version.
Neurology, Psychiatry & Brain Research is related to the oldest German speaking journal in this field, the Centralblatt fur Nervenheilkunde, Psychiatrie und gerichtliche Psychopathologie, founded in 1878. The tradition and idea of previous famous editors (Alois Alzheimer and Kurt Schneider among others) was continued in modernized form with Neurology, Psychiatry & Brain Research. Centralblatt was a journal of broad scope and relevance, now Neurology, Psychiatry & Brain Research represents a journal with translational and interdisciplinary perspective, focusing on clinically oriented research in psychiatry, neurology and neighboring fields of neurosciences and psychology/psychotherapy with a preference for biologically oriented research including basic research. Preference is given for papers from newly emerging fields, like clinical psychoimmunology/neuroimmunology, and ideas.
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