Molecular mechanisms of high-affinity interaction of the protein tBid with the mitochondrial complex МТСН2-МОАР-1

Abstract

Mitochondrial carrier homolog 2 (MTCH2) is a protein that plays an important role in the execution of apoptosis being a receptor for tBid in the outer membrane of mitochondria. Previously, it has been shown that the binding of the modulator of apoptosis-1 (MOAP-1) protein to MTCH2 is required for the efficient MTCH2-mediated recruitment of tBid to mitochondria and, in contrast, tBid is required for the MOAP-1 recruitment to mitochondria, but the structure understanding of these phenomena is absent. In this study, we have provided structural insights into the mechanisms of regulation of the MTCH2 receptor function for tBid by MOAP-1.