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Mechanochemical structural nanoengineering of heterooxide photocatalysts TiO2/ V2O5 capable to accumulating photoinduced charges 能够累积光诱导电荷的杂氧化物光催化剂 TiO2/ V2O5 的机械化学结构纳米工程
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-207-213
V. B. Shcherbakova, T. V. Sviridova, D. Sviridov, V. E. Agabekov
The mechanochemical method yielding a composite photocatalyst TiO2/V2O5 of tubular morphology under localized mechanic impact on a mixture of dispersed oxides has been proposed. It has been shown that under contact loading amounting to 25–39 MPa, tubular TiO2 is growing due to bonding of hydrated oxide particles via polycondensation. In the case of a mixture of titania and vanadium oxides, the tubular structure growth is accompanied with dispersing V2O5 particles resulting in the release of free standing lamellae. The mechanochemical activation produces nanоheterojunctions TiO2/V2O5 able to ensure an effective separation of photo-induced charges and their accumulation in redox active V2O5. Employing mechanochemical activation for synthesis of a TiO2/V2O5 composite photocatalyst results in 2.5-fold enhancement of the oxidation activity induced by preliminary photocatalyst exposure.
该研究提出了一种机械化学方法,在对分散氧化物混合物的局部机械冲击下,产生管状形态的复合光催化剂 TiO2/V2O5。研究表明,在 25-39 兆帕的接触载荷下,由于水合氧化物颗粒通过缩聚作用结合在一起,管状二氧化钛不断生长。在二氧化钛和钒氧化物的混合物中,管状结构的生长伴随着 V2O5 颗粒的分散,从而释放出独立的薄片。机械化学活化产生的纳米 TiO2/V2O5 互结能够确保有效分离光诱导电荷并将其积聚在具有氧化还原活性的 V2O5 中。采用机械化学活化法合成 TiO2/V2O5 复合光催化剂,可将初步光催化剂暴露诱导的氧化活性提高 2.5 倍。
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引用次数: 0
Analysis of the radiation effect on the activity of thyroid blood transport systems: connection with the features of thyroid status 分析辐射对甲状腺血液运输系统活性的影响:与甲状腺状态特征的联系
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-229-237
T. A. Mityukova
Thyroid-binding proteins play an important role in regulating thyroid status. However, the question of the radiation effect on the functional state of thyroid blood transport systems remains insufficiently studied. The aim of the work was to assess the indicators of thyroid status and thyroid blood transport in persons exposed to radiation as a result of the Chernobyl accident. The task of the work was also to analyze the results of an oral test for thyroxine pharmacokinetics in patients with thyroid carcinoma who received radioiodine therapy. Screening studies conducted 5−6 years after the Chernobyl accident indicate the radiation effect on the free thyroxine content in the blood and the functional activity of thyroid protein transport in children and adolescents living in the territories of the Khoiniki district of the Gomel region. The dose-dependent effect of an absorbed dose of 131I was also detected in children and adolescents displaced from the 30 km zone of the Chernobyl accident. The results of an oral test for thyroxine pharmacokinetics demonstrate an increase in the free T4 content against the background of a stable total T4 fraction in patients with thyroid carcinoma who received high dose loads as a result of radioiodine therapy. The conducted studies confirm the possibility of the influence of a high dose of 131I on thyroid blood transport systems and on the ratio of free and bound fractions of thyroid hormones in the blood.
甲状腺结合蛋白在调节甲状腺状态方面发挥着重要作用。然而,关于辐射对甲状腺血液运输系统功能状态的影响这一问题的研究仍然不足。这项工作的目的是评估切尔诺贝利事故辐射暴露者的甲状腺状态和甲状腺血液运输指标。这项工作的任务还包括分析接受放射性碘治疗的甲状腺癌患者的甲状腺素药代动力学口服测试结果。切尔诺贝利事故发生5-6年后进行的筛查研究表明,辐射对居住在戈梅利地区霍伊尼基(Khoiniki)地区的儿童和青少年血液中游离甲状腺素含量和甲状腺蛋白转运功能活动产生了影响。在切尔诺贝利事故 30 公里区域内流离失所的儿童和青少年中,也检测到了吸收剂量 131I 的剂量依赖效应。甲状腺素药代动力学口服测试结果表明,在接受高剂量放射性碘治疗的甲状腺癌患者体内,游离 T4 含量增加,而总 T4 含量保持稳定。研究证实,大剂量 131I 有可能对甲状腺血液运输系统以及血液中甲状腺激素的游离部分和结合部分的比例产生影响。
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引用次数: 0
Effect of VEGF gene polymorphism on the survival of a patient with non-small cell lung cancer 血管内皮生长因子基因多态性对非小细胞肺癌患者生存期的影响
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-220-228
M. N. Shapetska, A. Mikhalenka, A. Shchayuk, L. V. Mirilenko, L. V. Gorbatenko, A. Kilchevsky
Currently, much attention is paid to studying the vascular endothelial growth factor (VEGF) that stimulates angiogenesis, as a potential target for antiangiogenic therapy. The purpose of this work was to study the effect of polymorphic variants rs2010963 (G-634C), rs699947 (A-2578C), and rs3025039 (C+936T) of the VEGF gene, encoding a vascular endothelial growth factor, on the overall (OS) and adjusted survival (AS) of patients with non-small cell lung cancer (NSCLC) at stages I–III. The effect of VEGF rs699947 polymorphic variants on the extent of tumor spread was shown. A connection between AS and polymorphic variants rs2010963 (G-634C) and rs699947 (A-2578C) was established. The one-year adjusted survival (AS) in the -634G/C genotype carriers was 81.9 ± 3.9 %; in the -634G/G genotype carriers – 92.8 ± 2.5 %; and p = 0.016 was the significance level. Two-year AS was as follows: in the carriers of the -634G/C genotype was 70.4 ± 4.6 %; in the carriers of the -634G/G genotype – 84.3 ± 3.5 %; and p = 0.015. Three-year AS: in the carriers of the -634G/ genotype C was 63.0 ± 4.9 %; in the carriers of the -634G/G genotype – 76.7 ± 4.1 %; and p = 0.029. One-year and two-year AS in the carriers of the -2578A/A genotype was significantly higher than in the carriers of the -2578C/C genotype (p = 0.015 and p = 0.042 respectively). The identified influence of the polymorphic variants rs2010963 and rs699947 on the survival of NSCLC patients during the first three years after the established diagnosis shows a need to use knowledge about the genetic characteristics of a tumor during therapy.
目前,刺激血管生成的血管内皮生长因子(VEGF)作为抗血管生成治疗的潜在靶点受到了广泛关注。本研究旨在研究编码血管内皮生长因子的 VEGF 基因的多态变异 rs2010963 (G-634C)、rs699947 (A-2578C) 和 rs3025039 (C+936T)对 I-III 期非小细胞肺癌(NSCLC)患者的总生存期(OS)和调整生存期(AS)的影响。研究还显示了 VEGF rs699947 多态变异对肿瘤扩散程度的影响。AS与多态变异rs2010963(G-634C)和rs699947(A-2578C)之间的联系已被确定。-634G/C基因型携带者的一年调整生存率(AS)为81.9 ± 3.9%;-634G/G基因型携带者的一年调整生存率(AS)为92.8 ± 2.5%;P = 0.016为显著性水平。两年 AS 的情况如下:-634G/C 基因型携带者为 70.4 ± 4.6%;-634G/G 基因型携带者为 84.3 ± 3.5%;p = 0.015。三年 AS:-634G/基因型 C 携带者为 63.0 ± 4.9%;-634G/G 基因型携带者为 76.7 ± 4.1%;p = 0.029。-2578A/A基因型携带者一年和两年的AS明显高于-2578C/C基因型携带者(分别为p = 0.015和p = 0.042)。多态变异 rs2010963 和 rs699947 对 NSCLC 患者确诊后前三年的生存期有影响,这表明在治疗过程中需要利用肿瘤遗传特征方面的知识。
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引用次数: 0
Production traits of pigs of intrabreed type “Pripyatsky” in Landrace breed at breeding enterprises 育种企业陆地猪种 "普里皮亚季 "杂交猪的生产特征
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-255-264
I. Sheiko, R. I. Sheiko, N. V. Pristupa, E. A. Yanovich, V. N. Zayats, M. V. Krasovskaya
To meet the population’s demand for meat pork, breeding programs aimed at breeding and selection of pigs with high reproductive, fattening and meat traits were carried out for several decades. Over the years, a number of new types, lines and breeds of pigs were created and tested in the world. It should be noted that the gene pool of foreign super-meat breeds (Pietrain; Duroc; Danish, French, German, Canadian Landrace and Yorkshire) was used to some extent in the development of new domestic meat genotypes of pigs. A rational use of the genetic potential of farm animals allows accelerating the selection to improve their reproductive, fattening and meat traits. The Republic of Belarus arranged its own production of high-value animals represented by intrabreed type-pigs in the Landrace breed with the following productivity indicators: prolificacy – 12.5 animal units, milk yield – 65.5 kg, number of piglets at weaning – 11.6 animal units, litter weight at weaning at the age of 30 days – 91.6 kg, meat content in carcass – 65–67 %, well adapted to the technological conditions of breeding and industrial complexes, providing the overall need of pig breeding in obtaining high-quality pork; saving foreign currency for import; the possibility of exporting finished products to CIS countries.
为了满足人们对肉猪的需求,几十年来,旨在培育和选育繁殖力强、育肥和肉质好的猪的育种计划一直在进行。多年来,世界上出现了许多猪的新类型、新品系和新品种,并进行了试验。值得注意的是,国外超级肉猪品种(皮特兰、杜洛克、丹麦、法国、德国、加拿大陆地猪和约克夏)的基因库在一定程度上被用于开发新的国内肉猪基因型。合理利用农场动物的遗传潜力可以加快选育工作,改善其繁殖、育肥和肉质特性。白俄罗斯共和国自己生产的高价值牲畜的代表是兰德瑞种猪,其生产性能指标如下:多产 - 12.5 头,产奶量 - 65.5 公斤,断奶仔猪数 - 11.6 头,30 日龄断奶窝重 - 91.6 kg,胴体含肉量 - 65-67%,很好地适应了育种和工业综合体的技术条件,满足了养猪业获得优质猪肉的总体需要;节省了进口外汇;可以向独联体国家出口成品。
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引用次数: 0
De novo design and virtual screening of potential Bcr-Abl tyrosine kinase inhibitors using deep learning and molecular modeling technologies 利用深度学习和分子建模技术从头设计和虚拟筛选潜在的 Bcr-Abl 酪氨酸激酶抑制剂
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-196-206
А. М. Андрианов, К. В. Фурс, А. Д. Карпенко, Т. Д. Войтко, А. В. Тузиков, A. M. Andrianov, K. V. Furs, A. D. Karpenko, Timofey D. Vaitko, Corresponding Member, A. Tuzikov
De novo design and virtual screening of small-molecule compounds with a high potential inhibitory activity against the Bcr-Abl tyrosine kinase playing a key role in the pathogenesis of chronic myeloid leukemia (CML) were carried out by an integrated computational approach including technologies of deep learning and molecular modeling. As a result, according to the calculation data we identified 5 compounds exhibiting low values of binding free energy to the enzyme comparable with those predicted for imatinib, nilotinib and ponatinib, anticancer drugs widely used in the clinic to treat patients with CML. It was shown that these compounds are able to form stable complexes with the ATP-binding sites of the Bcr-Abl tyrosine kinase and its mutant form T315I, which is confirmed by the analysis of the profiles of binding affinity and intermolecular interactions responsible for their energy stabilization. Based on the obtained data, these compounds, which have been generated by the deep learning neural network, are assumed to form promising basic structures for development of new effective drugs for treatment of patients with CML.
我们采用深度学习和分子建模技术等综合计算方法,对在慢性髓性白血病(CML)发病机制中起关键作用的Bcr-Abl酪氨酸激酶具有高潜在抑制活性的小分子化合物进行了全新设计和虚拟筛选。结果,根据计算数据,我们确定了 5 种化合物,它们与该酶的结合自由能值较低,与伊马替尼、尼洛替尼和泊纳替尼(临床上广泛用于治疗 CML 患者的抗癌药物)的结合自由能值相当。研究表明,这些化合物能够与 Bcr-Abl 酪氨酸激酶及其突变体 T315I 的 ATP 结合位点形成稳定的复合物,这一点通过分析其结合亲和力和分子间相互作用的能量稳定曲线得到了证实。根据所获得的数据,这些由深度学习神经网络生成的化合物被认为有望形成基本结构,用于开发治疗慢性骨髓性白血病患者的有效新药。
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引用次数: 0
About one strengthening of the Massera’s existence theorem of periodic solutions of linear differential periodic systems 关于线性微分周期系统周期解的马塞拉存在定理的一次强化
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-188-195
A. Demenchuk, A. V. Konuh
According to Massera’s theorem, an ordinary differential linear nonhomogeneous periodic system has a periodic solution with a period coinciding with that of the system if and only if this system has a bounded solution. We introduce the class L of vector functions called growing slower than a linear function. This class contains the class B of bounded vector functions in as its own subclass. It has been proved that Massera’s above-mentioned theorem will remain true if in its formulation a bounded solution is replaced by a slower growing solution than a linear function. It is shown that the set B in the metric space (L, distc ), where distc is the uniform convergence metric vector functions on intervals, has Baer’s first category, i. e. almost everything in the sense of the category of space vector functions (L, distc ) are not bounded. This fact shows the significance of the obtained strengthening of Massera’s theorem.
根据马塞拉定理,当且仅当一个常微分线性非均质周期系统具有有界解时,该系统才具有周期与系统周期重合的周期解。我们引入了称为比线性函数增长慢的矢量函数类 L。该类包含有界矢量函数类 B 作为自己的子类。已经证明,如果在马塞拉定理的表述中用比线性函数增长慢的解代替有界解,那么马塞拉定理仍然成立。研究表明,度量空间(L,distc )中的集合 B(其中 distc 是区间上的均匀收敛度量矢量函数)具有 Baer 的第一类别,即空间矢量函数类别(L,distc )意义上的几乎所有东西都不是有界的。这一事实表明了所得到的马塞拉定理强化的意义。
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引用次数: 0
Asymptotic method for solving the problem of transition process optimization in a three-tempo singularly perturbed system 解决三时刻奇异扰动系统中过渡过程优化问题的渐近方法
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-183-187
A. I. Kalinin, L. I. Lavrinovich
The problem of constructing a transition process with minimal energy costs for a linear singularly perturbed system containing three groups of variables with significantly different rates of change is considered. Asymptotic approximations to solving this problem are constructed in the form of an open-loop and feedback controls. The main advantage of the proposed computational procedures is that the original problem is split into three unperturbed optimal control problems of lower dimension.
对于一个包含三组变化率明显不同的变量的线性奇异扰动系统来说,如何构建一个能量成本最小的过渡过程是一个需要考虑的问题。以开环和反馈控制的形式构建了解决这一问题的渐近近似值。提出的计算程序的主要优势在于,原始问题被拆分为三个维度较低的未扰动最优控制问题。
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引用次数: 0
Composite coatings of poly(methyl methacrylate) with silicon dioxide nanoparticles for capacitive sensors of nickel content control in water 聚(甲基丙烯酸甲酯)与二氧化硅纳米颗粒的复合涂层,用于控制水中镍含量的电容式传感器
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-247-254
D. V. Sapsaliou, G. Melnikova, A. V. Aksiuchyts, T. Tolstaya, D. A. Kotov, S. Chizhik
Pollution of the environment, in particular water sources, with heavy metals is a serious environmental problem. In this regard, it is relevant to develop new sensor systems that allow rapid tests and are not inferior in analytical parameters to classical methods for detecting heavy metals. Promising materials for creating such sensor systems are composite coatings based on polymer compounds with inorganic nanoparticles. The article presents the results of using poly(methyl methacrylate) (PMMA) coatings and PMMA nanocomposites with silicon dioxide nanoparticles (SiO2 NPs) to develop capacitive sensors for analyzing the content of Ni2+ ions in water. The structural and morphological characteristics of a conductive nickel layer and nanostructured films based on poly(methyl methacrylate) were studied using atomic force microscopy. Based on the experimental data on the dependence of the capacitance characteristics of sensors on the concentration of Ni2+ in solutions, the operating characteristics of sensors were established: response time is 5 min; working range of concentrations of Ni2+ ions: 1 ‧ 10–3 – 50 mM; lower detection limit ≈ 0.06 mg/l (maximum nickel concentration limit in water is 0.1 mg/l). It has been shown that the formation of a coating of the composition PMMA + NPs-SiO2 (1 : 41.7 mol) on a conductive nickel layer using the spin-coating method leads to increasing the sensitivity of a sensor and its service life (up to seven cycles).
重金属污染环境,尤其是污染水源,是一个严重的环境问题。因此,有必要开发新的传感器系统,以实现快速检测,并且在分析参数上不逊色于传统的重金属检测方法。基于聚合物化合物和无机纳米颗粒的复合涂层是创建此类传感器系统的理想材料。文章介绍了使用聚甲基丙烯酸甲酯(PMMA)涂层和 PMMA 纳米复合材料与二氧化硅纳米粒子(SiO2 NPs)开发电容式传感器以分析水中 Ni2+ 离子含量的结果。使用原子力显微镜研究了导电镍层和基于聚甲基丙烯酸甲酯的纳米结构薄膜的结构和形态特征。根据传感器电容特性与溶液中 Ni2+ 浓度关系的实验数据,确定了传感器的工作特性:响应时间为 5 分钟;Ni2+ 离子浓度的工作范围:1 ‧ 10-3 - 50 毫摩尔;检测下限≈ 0.06 毫克/升(水中镍浓度上限为 0.1 毫克/升)。研究表明,使用旋涂法在导电镍层上形成一层 PMMA + NPs-SiO2 (1:41.7 mol)的涂层,可提高传感器的灵敏度和使用寿命(最多七个周期)。
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引用次数: 0
About two new families of acanthodian fishes (Acanthodii) 关于刺鳑鲏鱼(Acanthodii)的两个新科
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-214-219
D. P. Plax
The article presents some information on two new families of Ptychodictyidae fam. nov. and Nostolepidae fam. nov. that were established on the basis of the author’s personal research and the available literature data. Their main diagnostic features, generic composition, number of species, comparison, stratigraphic and geographical distribution are given. The obtained data supplement the taxonomy of the Palaeozoic acanthodian fishes.
文章介绍了作者根据个人研究和现有文献资料建立的两个新科 Ptychodictyidae fam.文中给出了它们的主要诊断特征、类属组成、种数、比较、地层和地理分布。所获得的数据补充了古生代棘鱼的分类学。
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引用次数: 0
Numerical modeling of microclimate of re-waterlogged lands of Belarusian Polesie 白俄罗斯波列西再涝土地小气候数值模拟
Pub Date : 2024-07-08 DOI: 10.29235/1561-8323-2024-68-3-238-246
С. А. Лысенко, Sergey А. Lysenko, © Лысенко
Based on the mesoscale hydrodynamic model WRF (Weather Research and Forecasting), the balance model of atmospheric moisture and the remote sensing data, we obtained the estimates of microclimate changes as a result of reswamping of lands in Belarusian Polesie. The calculations were performed on the example of the Khoiniki district of the Gomel region of Belarus. Numerical experiments considered the driest summer periods of the last two decades. Based on the modeling results, the maps of changes in mean daily temperature, amplitude of daily temperature variations, evapotranspiration and precipitation were constructed, which can be used to predict the consequences of land reclamation in different scenarios of adaptation to climate changes.
根据中尺度流体力学模型 WRF(天气研究与预报)、大气湿度平衡模型和遥感数据,我们获得了白俄罗斯波列西地区土地重新沼泽化后小气候变化的估计值。计算以白俄罗斯戈梅利州霍伊尼基地区为例进行。数值实验考虑了过去二十年中最干旱的夏季。根据建模结果,绘制了日平均气温、日气温变化幅度、蒸散量和降水量的变化图,可用于预测在适应气候变化的不同情况下土地开垦的后果。
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引用次数: 0
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Doklady of the National Academy of Sciences of Belarus
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