A Biodegradable Mesh-Covered Drug Eluting Coronary Embolic Protection Stent: A Promising Solution for Embolization Treatment for Coronary Arteries

Abstract

      The newly developed "Mesh Covered Drug Eluting Coronary Embolic Protection Stent" is specifically designed to address the problem of distal embolization during percutaneous coronary intervention (PCI), a common procedure for treating myocardial infarction. This study aimed to evaluate the strength of the mesh component in patients with coronary artery disease. The stent system consists of a cobalt-chromium metal stent covered with a knitted mesh made of biodegradable PLGA polymer, which effectively prevents embolic events. The findings of the study demonstrated that the stent system exhibited high radial strength, withstanding significant levels of deformation before failure. This indicates that the mesh covered drug eluting coronary embolic protection stent has the potential to effectively mitigate distal embolization during PCI. The use of a biodegradable mesh in conjunction with the stent offers advantages over traditional stents by reducing the risk of restenosis, thrombosis, and inflammation, thereby improving long-term outcomes. Through bench-scale experiments, we have verified that the "Mesh Covered Drug Eluting Coronary Embolic Protection Stent" exhibits robust strength, validating its potential as an effective solution for addressing distal embolization during percutaneous coronary intervention.