Correlation of Myeloperoxidase and Carotid Atherosclerosis in Non-diabetic Patients with Maintenance Hemodialysis

中国动脉硬化杂志 Pub Date : 2011-01-01 DOI:10.3760/CMA.J.ISSN.1008-6315.2013.03.012

Zhanyun Zhao, B. Yan, Song Li, L. Hao, Li Yin

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Abstract

Objective To study possible clinical relationships of myeloperoxidase (MPO) and carotid atherosclerosis in diabetic patients on maintenance hemodialysis(MHD).Methods Levels of plasma MPO and serum elastase (ELT) of diabetic patients on MHD were determined by enzyme-linked immunosorbent assay.Carotid intima media thickness(CIMT),quantity and area of carotid plaque were measured by B-mode ultrasonography.Results Plasma MPO was significantly higher after hemodialysis(HD) than before HD(414.6 (198.9,671.5) μg/L vs 176.4 (69.9,243.3) μg/L,Z =-4.51,P ＜ 0.01).There was no significant difference of serum ELT before and after HD(198.0(146.9,270.5) μg/L vs 230.9(40.2,308.0) μg/L,Z =-1.87,P ＞ 0.05).There was positive correlation between the age and CIMT,quantity or area of carotid plaqueor(correlation coefficient:0.764,0.416 and 0.446 respectively,P ＜ 0.01 or P ＜ 0.05),There was positive correlation between MPO level before HD and age,Levels of serum ELT before HD,or CIMT(correlation coefficient:0.592,0.476 and 0.810 respectively,P ＜ 0.01).There was positive correlation between MPO level after HD and levels of serum ELT after HD (correlation coefficient:0.364,P ＜ 0.05).There was no correlation between the levels of plasma MPO after HD and CIMT,quantity or area of carotid plaqueor (P ＞ 0.05).Conclusion (1) Age and MPO level before HD contribute to carotid atherosclerosis in patients on MHD.(2)There was no relation between higher MPO level after HD and carotid atherosclerosis. Key words: Hemodialysis; Myeloperoxidase ; Diabetic ; Carotid atherosclerosis disease

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非糖尿病维持性血液透析患者髓过氧化物酶与颈动脉粥样硬化的相关性

目的探讨糖尿病维持性血液透析(MHD)患者髓过氧化物酶(MPO)水平与颈动脉粥样硬化的关系。方法采用酶联免疫吸附法测定糖尿病MHD患者血浆MPO和血清弹性酶(ELT)水平。b超测量颈动脉内膜中膜厚度(CIMT)、颈动脉斑块数量及面积。结果血液透析(HD)后血浆MPO明显高于HD前(414.6 (198.9671.5)μg/L vs 176.4 (69.9243.3) μg/L,Z =-4.51,P < 0.01)。HD前后血清ELT (198.0(146.9270.5) μg/L vs (2230.9 (40.2308.0) μg/L,Z =-1.87,P > 0.05)差异无统计学意义。年龄与颈动脉斑块数量、面积呈正相关(相关系数分别为0.764、0.416、0.446,P < 0.01或P < 0.05)， HD前MPO水平与年龄、HD前血清ELT水平、CIMT水平呈正相关(相关系数分别为0.592、0.476、0.810,P < 0.01)。HD后MPO水平与HD后血清ELT水平呈正相关(相关系数为0.364,P < 0.05)。HD后血浆MPO水平与颈动脉CIMT、颈动脉斑块数量和面积无相关性(P > 0.05)。结论(1)HD患者颈动脉粥样硬化与年龄、HD前MPO水平有关。(2)HD后MPO水平升高与颈动脉粥样硬化无相关性。关键词:血液透析;髓过氧化物酶;糖尿病;颈动脉粥样硬化

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来源期刊

中国动脉硬化杂志

CiteScore

0.40

自引率

0.00%

发文量

6576

期刊介绍： Chinese Journal of Arteriosclerosis (CN 43-1262/R, ISSN 1007-3949) is a professional academic journal governed by China Association for Science and Technology and sponsored by Chinese Association of Pathophysiology and University of South China. The publishing scope of the journal includes the prevention and treatment of arteriosclerotic diseases (such as hyperlipidemia, coronary artery disease, ischemic cerebrovascular disease, hypertension, arteriosclerosis and other ischemic diseases) in traditional Chinese medicine, preventive medicine, basic medicine, clinical medicine, pharmacology and special medicine. The columns include original research article (including epidemiological research, experimental research, clinical research and methodological research), review, diagnosis and treatment experience, case report, lectures, etc. The aim of the journal is to report cutting-edge theories, viewpoints, therapies and new drugs for the prevention and treatment of arteriosclerotic diseases, introduce new experience and knowledge of prevention and control, facilitate academic research and promote academic exchanges at home and abroad, and promote the improvement of human health. Chinese Journal of Arteriosclerosis was selected as the core journal of the 2014 edition of Chinese Core Journals Catalog. The Journal was rated as RCCSE Chinese Core Academic Journal in the Chinese Academic journals Evaluation Report (2009-2010). The journal is also indexed by the Statistical Source of Chinese Scientific and Technological Papers (China Scientific and Technological Core Journal) of the Ministry of Science and Technology, Chemical Abstract (CA), Russian Abstract Journal (AJ), Wanfang Data, Chinese Academic Journals (CNKI) and other well-known retrieval databases.