Population pharmacokinetics of cisplatin in Asian Indian cancer patients

Abstract

The aim of this study was to describe population pharmacokinetics of cisplatin in an Indian cancer population. Dosage adjustment based on individual pharmacokinetic parameters is of considerable importance for effective and safe use of drugs. Extensive work on cisplatin and other was carried out in different cancer patient populations, but no data are available in Indian cancer patients. In the present study 154 steady state concentrations of cisplatin were analyzed from 46 patients. Pharmacostatistical work was done by using NONMEM. The covariates evaluated in this study were age, body weight, height, sex, and creatinine clearance. The model found to best describe the data following the FO and FOCE method was: Clearance (CL) = θ1*(CLCR/74.92) *EXP (η1) and Volume (V) = {θ2 *(AGE/52.3) + θ3*(BSA/1.55)}*EXP (η2). The final model estimates of CL and V estimated by FO method were 3.02 L/h and 2.72 L, respectively, and by FOCE method were 3.39 L/h and 4.48 L, respectively. These parameters are utilized for individualizing the loading and maintenance doses in pediatric patients.