The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients.

IF 2.5 4区工程技术 Q3 ENGINEERING, ELECTRICAL & ELECTRONIC Journal of Electronic Materials Pub Date : 2023-10-27 DOI:10.5937/jomb0-43154

Jasna Klen, Katja Goričar, Vita Dolžan

引用次数: 0

Abstract

Background: Besides good glycemic control, also control of lipid levels can effectively prevent or delay late type 2 diabetes (T2D) complications. As apolipoprotein E (APOE) and paraoxonase 1 (PON1) were shown to suppress atherosclerosis, we investigated the associations of common functional PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in T2D patients.

Methods: Our retrospective genetic association study included 181 T2D patients genotyped for PON1 rs622, PON1 rs854560, APOE rs429358 and APOE rs7412.

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PON1 和 APOE 多态性与 2 型糖尿病患者血浆脂质水平和晚期并发症风险的关系。

背景：除了良好的血糖控制，控制血脂水平也能有效预防或延缓 2 型糖尿病（T2D）后期并发症。由于载脂蛋白 E（APOE）和副氧自由基酶 1（PON1）具有抑制动脉粥样硬化的作用，我们研究了常见功能性 PON1 和 APOE 多态性与 T2D 患者血浆脂质水平和晚期并发症风险的关系：我们的回顾性遗传关联研究纳入了 181 名 T2D 患者，对 PON1 rs622、PON1 rs854560、APOE rs429358 和 APOE rs7412 进行了基因分型。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Electronic Materials 工程技术-材料科学：综合

CiteScore

4.10

自引率

4.80%

发文量

693

审稿时长

3.8 months

期刊介绍： The Journal of Electronic Materials (JEM) reports monthly on the science and technology of electronic materials, while examining new applications for semiconductors, magnetic alloys, dielectrics, nanoscale materials, and photonic materials. The journal welcomes articles on methods for preparing and evaluating the chemical, physical, electronic, and optical properties of these materials. Specific areas of interest are materials for state-of-the-art transistors, nanotechnology, electronic packaging, detectors, emitters, metallization, superconductivity, and energy applications. Review papers on current topics enable individuals in the field of electronics to keep abreast of activities in areas peripheral to their own. JEM also selects papers from conferences such as the Electronic Materials Conference, the U.S. Workshop on the Physics and Chemistry of II-VI Materials, and the International Conference on Thermoelectrics. It benefits both specialists and non-specialists in the electronic materials field. A journal of The Minerals, Metals & Materials Society.