THE EFFECT OF NERVE GROWTH FACTOR ON INDICATORS OF THE ANTIOXIDANT SYSTEM IN RAT BRAIN TISSUE

Abstract

The work was to study the effect of nerve growth factor (NGF) on the parameters of the antioxidant system in the rat brain. From the submandibular salivary glands of male mice, we isolated and purified fractions with nerve growth activity. We study the effect of NGF on the parameters of the antioxidant system – catalase, superoxide dismutase (SOD), and malon dialdehyde (MDA). It was found that the activity of catalase increases at a concentration of NGF of 5 μg, with a further growth of concentration of NGF a decrease in the activity of the enzyme was observed. SOD activity tends to increase at NGF concentrations of 5 and 25 μg. The decrease in the content of MDA is pronounced with the introduction of various concentrations of NGF. Thus, the activity of antioxidant enzymes tends to be restored in the presence of NGF. Neuroprotectors can exhibit therapeutic efficacy of antioxidants in neurodegenerative diseases and ischemic brain damage.