Screening and model construction of the clinical diagnostic indictors for Kashin-Beck disease in adolescents

Q3 Medicine 中华地方病学杂志 Pub Date : 2011-11-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2011.06.026

C. Cao, Xiong Guo, Yong-zhong Zhang

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引用次数: 1

Abstract

Objective To understand the relationship between clinical manifestations and Kashin-Beck disease(KBD) and their contribution to diagnosis of KBD and to construct the diagnosis model for KBD in adolescents.Methods A total of 2248 subjects under the age of 18 were collected from 6 KBD endemic and 1 non-KBD areas of the Shaanxi province in China.Analysis of 32 indicators,including gender,age,and KBD clinical indicators.Indicators of the distribution of measurement data between the two groups using t test and analysis of variance,x2 test with count data,multi-category ordered response variables Logistic regression analysis for model building.Results It showed the KBD prevalence rate in adolescent had an increasing tendency with age.Analysis of indicators between the two groups,in addition to the age factor(P ＜ 0.05),the difference of ankle pain,knee pain,wrist movement disorder and other 5 indicators(P ＜ 0.05) and the last bend,elbow movement disorder,syndactyly and other 9 indicators(P ＜ 0.01 ) were statistically significant.Sixteen clinical and radiographic features in the clinical manifestations were significantly related with the clinical severity grading with KBD(P ＜ 0.01 ).Four models on the diagnostic indictors were constructed by cumulative logit model for adolescent KBD (-21ogL,Score,Wald x2 test,P ＜ 0.01 ).Conclusions The establishment of the diagnostic model based on their contribution of the joint involvement in systemic performance-related indicators has an important role for clinical diagnosis of KBD. Key words: Kashin Beck disease; Diagnosis; Symptoms; Physical signs

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青少年大骨节病临床诊断指标筛选及模型构建

目的了解大骨节病的临床表现与大骨节病的关系及其对大骨节病诊断的贡献，建立青少年大骨节病的诊断模型。方法在陕西省6个大肠癌流行区和1个非大肠癌流行区收集年龄在18岁以下的2248名调查对象。分析32项指标，包括性别、年龄、大骨节临床指标。各指标计量资料在两组间的分布情况采用t检验和方差分析，x2检验采用计数资料，多类别有序响应变量采用Logistic回归分析建立模型。结果青少年大骨节患病率随年龄增长呈上升趋势。两组间指标分析，除年龄因素(P < 0.05)外，踝关节疼痛、膝关节疼痛、腕关节运动障碍等5项指标(P < 0.05)和末节屈曲、肘关节运动障碍、并指等9项指标(P < 0.01)差异均有统计学意义。临床表现中的16项临床及影像学特征与大骨节病的临床严重程度分级有显著相关性(P < 0.01)。采用累积logit模型构建4个青少年大骨节病诊断指标模型(-21ogL,Score,Wald x2检验，P < 0.01)。结论基于二者共同参与系统绩效相关指标的贡献建立诊断模型，对大骨节病的临床诊断具有重要意义。关键词:大骨节病;诊断;症状;体征

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.