Determination of Biological Activities of Salvia sclarea L.

Abstract

Within the last two or three decades the treatment of the neurodegenerative disorders became became the main focus of the researches. In this, our aim was to determine some biological activities of the ethanolic and methanolic extracts of Salvia sclarea L. After obtaining the extracts, first they have been tested for their DPPH radical scavenging activity and then the total phenolic contents of the extracts have been identified. Afterwords, the extracts were evaluated for both their effects on acetylcholinesterase (AChE) and monoamine oxidase-A. These two enzymes are very important enyzmes for their importance in the treatment of neurodegenerative disorders. AChE plays a very crucial role especially in Alzheimer’s Disease. Monoamine oxidases and their inhibitors have also critical value in Alzheimer type dementia and in other neurologic diseases. It has been found that DPPH activity of the methanolic extract was higher than that of ethanolic extracts; while TPC was higher for the ethanolic extract. IC50 values were found for both AChE and MAO-A. For AChE the IC50 values for ethanolic extract and methanolic extract were, 0,27±0,005 mg/mL and 1,19±0,037 mg/mL; respectively. And for MAO-A the IC50 values for ethanolic extract and methanolic extract were 6,53±0,72 microgramg/mL and 3,03±0,05 microgram/mL; respectively.