Bio-speckle flowmetry for retinal blood flow diagnostics

Y. Aizu, T. Asakura, K. Ogino, T. Sugita, Yasuyuki Suzuki, K. Masuda
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引用次数: 19

Abstract

Bio-speckle flowmetry for measuring the retinal blood flow velocity is described. The measuring principle is briefly discussed in comparison with the laser Doppler method. The basic properties of the photon correlation measurements including reproducibility were experimentally investigated with a rotating ground glass disk and for the normal human retina. The error was estimated to be less than 20% for in vivo measurements. By using a glass capillary model, the reciprocal of correlation time was calibrated to the mean flow velocity with a consideration of the effects of the vessel diameter and the background reflectance. The blood flow volume rate in the human retina was estimated by using the calibrated velocity and the vessel diameter. The results compared well with those reported in the literature, and show the usefulness of this flowmetry for clinical diagnostic purposes.
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生物斑点血流法用于视网膜血流诊断
描述了用于测量视网膜血流速度的生物散斑血流法。简要讨论了测量原理,并与激光多普勒法进行了比较。用旋转磨砂玻璃盘和正常人视网膜实验研究了光子相关测量的基本性质,包括再现性。体内测量的误差估计小于20%。利用玻璃毛细管模型,在考虑血管直径和背景反射率影响的情况下,将相关时间倒数标定为平均流速。利用标定后的流速和血管直径来估计人视网膜的血流体积率。结果与文献报道的结果相比较,显示了该血流法在临床诊断中的实用性。
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