Outcome of Acute Kidney Injury (AKI) in Coronavirus Disease 2019 (COVID-19) patients

Abstract

Background: Coronavirus Disease 2019 (COVID-19) is a globally emerging illness, resulting in potential effects on public health and global economies. Objectives: To assess the incidence of Acute Kidney Injury among patients who are infected with COVID-19, and to evaluate risk factors. Patients and methods: This study enrolled 100 adult patients infected with COVID-19 and recently diagnosed with polymerase chain reaction (PCR). The patients were submitted to clinical examination and laboratory testing for ESR, CRP, CBC, Serum creatinine, and D-dimer. Patients were also assessed radiologically by CT Chest. High-resolution computed tomography Parenchymal abnormalities on HRCT were assessed. AKI patients were classified based on Acute Kidney Injury Network staging. Results : The mean age of all studied patients was 48.1 ± 10.8 years and mean BMI of all studied patients was 31.3 ± 4.6 kg/m 2 , 51 patients were males (51%) and 49 females (49%). There were 35 patients (35%) with a mild infection, 23 patients (23%) with moderate and 42 patients (42%) with severe in the studied patients. The overall AKI prevalence among COVID-19 patients was 18 %. All of them were grade III AKI. Our study revealed that old age, severity of infection, dyspnea, elevated CRP, ALT, AST, PT, INR, Urea and Creatinine were considerable distinct predictors for AKI. Conclusion : The Prevalence of AKI among COVID-19 patients was 18 %. Old age, the severity of infection, dyspnea, elevated CRP, increased serum urea, Creatinine were significant independent predictors for AKI.