Effect of Oxidative Stress on Iraqi Rheumatoid Arthritis Patients

Abstract

Oxidative stress is an imbalance between oxidants and antioxidants, play an important role in the development of Rheumatoid Arthritis. Rheumatoid Arthritis regard as a chronic, autoimmune disease. The aim of the study to assess levels of some oxidative stress biomarker in Rheumatoid Arthritis. This study involves 80 Rheumatoid arthritis patients and 30 healthy subjects as control groups. Analysis on serum samples was Malondialdehyde, Albumin, and total Bilirubin. The obtained data showed significantly increasing (P<0.01) in level of oxidant parameter Malondialdehyde and significantly decrease (P<0.01) in endogenous antioxidant albumin and total bilirubin in comparison with the control group which may be due to increased activity of immune system which involves reactive oxygen species in its action. The reactive oxygen species of originated from the immune system have the crucial role in oxidative stress situation in Rheumatoid arthritis