Aminoglycoside Resistance Pattern in Staphylococcus aureusat Hyderabad, Pakistan

Abstract

A total of 118 Staphylococcusaureus isolates from various clinical and non-clinical sources were processed for the determination of antibiotic resistance against a set of aminoglycoside group of antibiotics. In this study,44% (n=52) isolates were from various clinical specimens i.e. pus, blood and nose, while 56% (n=66) were recovered from the skin surfaces of healthy volunteers representing the non-clinical isolates. The highest percentage of resistance among both clinical and non-clinical isolates was observed against Neomycin (i.e. clinical = 86.5%, non-clinical = 39.3%). The lowest percentage of resistance among both clinical and non-clinical isolates was observed against Gentamycin (i.e. clinical = 34.6%, non-clinical = 4.5%). The percentage of difference for Amikacin, Gentamycin and To bramycin resistance between clinical non-clinical isolates was observed to be more than 100. The Odd Ratio for Amikacin, Gentamycin and Tobramycin resistance between clinical and non-clinical isolates was 17.75, 11.12, and 20.59, respectively while the p-values were determined as 0.0001 in all the three cases, suggesting a significant association of Amikacin, Gentamycin and Tobramycin resistance with clinical S.aureusisolates.