Synthesis and Characterization of Chitosan-Citrate Microparticle Using Ionic Gelation Methods

J. Latupeirissa, M. Tanasale, E. Fransina, Alesya Noya
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Abstract

A study has been conducted aimed to synthesize chitosan-citrate using the ionic gelation method and its characterization with FTIR, SEM, SAA, and PSA, as well as solubility and swelling tests. The results showed that chitosan reacted with sodium citrate producing chitosan-citrate particles. The product of chitosan-citrate has a rough and thickened surface morphology. Surface area is obtained by 35.233 m2/g and pore size is 0.027 cc/g, smaller than chitosan. Based on solubility and swelling tests in acidic, alkaline, and neutral media, chitosan-citrate has good resistance and low swelling effect.
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离子凝胶法制备壳聚糖-柠檬酸盐微粒及其表征
采用离子凝胶法制备了壳聚糖-柠檬酸盐,并用FTIR、SEM、SAA和PSA对其进行了表征,并对其溶解度和溶胀性进行了测试。结果表明,壳聚糖与柠檬酸钠反应生成壳聚糖-柠檬酸颗粒。壳聚糖-柠檬酸盐的产物具有粗糙和增厚的表面形貌。比表面积为35.233 m2/g,孔径为0.027 cc/g,比壳聚糖小。在酸性、碱性和中性介质中的溶解度和溶胀试验表明,壳聚糖柠檬酸盐具有良好的抗溶胀性和低溶胀性。
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