Active Component in Green Tea Catechins and Effective Intake Period for Prevention of Age-related Brain Dysfunction

K. Unno, Hiroyuki Yamamoto, Toshiya Ohtaki, Y. Ishikawa, Shigenori Noda, Ken-ichi Maeda, Keisuke Fujitani, Hideaki Miyazaki, Fumiyo Takabayashi, Toru Sasaki, M. Hoshino
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引用次数: 6

Abstract

Objective: We previously found that green tea catechins (GT-catechin) decrease oxidative damage to DNA and suppress brain dysfunction in aged senescence-accelerated mice (SAMP10). To clarify the effect of GT-catechin on suppression of brain dysfunction, we compare the effect on learning ability among several catechins and examined the essential intake period for prevention of brain dysfunction.Methods: Male SAMP10 mice were allowed free access to water containing epigallocatechin gallate (EGCG, 0.06 mg/ml), epigallocatechin (EGC, 0.03 mg/ml), GT-catechin (0.2 mg/ml), or green tea extract (0.66 mg/ml). Learning ability of mice was measured using a step-through passive avoidance task.Results: SAMP10 mice exhibit brain dysfunction with aging. However, learning ability was significantly higher in mice that drank GT-catechin and EGCG than same-aged control mice that drank water. EGCG was an important component, but EGC had no effect on learning ability. The learning ability was significantly improved in mice that ingested EGCG for > 5 months, and tended to improve in mice that ingested EGCG for 2 or 3 months. Next, the level of synaptophysin, a marker of presynapse, tended to be higher in mice that ingested EGCG but not in mice that ingested EGC. The levels of synaptophysin were significantly higher in mice ingested GT-catechin and green tea extract than control mice.Conclusion: The intake of EGCG, the major catechin in green tea, but not EGC, suppressed age-related brain dysfunction. The effective intake period of EGCG was > 5 months for suppression of brain dysfunction.
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绿茶儿茶素的活性成分及有效摄入期预防老年性脑功能障碍
目的:我们之前发现绿茶儿茶素(GT-catechin)可以减少衰老加速小鼠(SAMP10)对DNA的氧化损伤,抑制脑功能障碍。为了阐明gt -儿茶素对脑功能障碍的抑制作用,我们比较了几种儿茶素对学习能力的影响,并考察了预防脑功能障碍的必要摄入时间。方法:雄性SAMP10小鼠自由接触含有没食子儿茶素没食子酸酯(EGCG, 0.06 mg/ml)、没食子儿茶素(EGC, 0.03 mg/ml)、gt儿茶素(0.2 mg/ml)或绿茶提取物(0.66 mg/ml)的水。采用步进式被动回避任务测量小鼠的学习能力。结果:SAMP10小鼠随年龄增长出现脑功能障碍。然而,饮用gt -儿茶素和EGCG的小鼠的学习能力明显高于喝水的同龄对照小鼠。EGCG是重要成分,但EGC对学习能力没有影响。摄入EGCG > 5个月的小鼠学习能力显著提高,摄入EGCG 2、3个月的小鼠有改善的趋势。接下来,突触素(突触前的一种标记物)的水平在摄入EGCG的小鼠中趋于较高,而在摄入EGC的小鼠中则没有。摄入gt -儿茶素和绿茶提取物的小鼠突触素水平明显高于对照组小鼠。结论:摄入绿茶中主要的儿茶素EGCG,而不是EGC,可以抑制与年龄相关的脑功能障碍。EGCG对脑功能障碍的抑制作用有效摄入期> 5个月。
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