{"title":"元・編集長のページ 新しい英文雑誌npj Aging and Mechanisms of Disease創刊に向けて","authors":"坪田 一男","doi":"10.1038/41514.2056-3973","DOIUrl":"https://doi.org/10.1038/41514.2056-3973","url":null,"abstract":"","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"21 1","pages":"577-581"},"PeriodicalIF":0.0,"publicationDate":"2014-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81459390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Sumida, Y. Naito, E. Hashimoto, W. Aoi, Yutaka Takahashi, Y. Yonei, T. Yoshikawa
Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease caused primarily by obesity, and its incidence among Japanese adults is rapidly rising at 10-40%. Most NAFLD presents as simple steatosis, but some are nonalcoholic steatohepatitis (NASH) progressing to hepatic cirrhosis or hepatocellular carcinoma. NAFLD is diagnosed by the following three features; (1) alcohol non-consumers (“non-drinkers”), (2) steatosis, and (3) exclusion of liver disease caused by other factors, with non-drinkers including light consumers of alcohol in amounts not engendering alcoholic liver disease. Dietary treatment is the basis of therapy, but evidence concerning exercise therapy has accumulated recently, and its mechanisms have been explained. Dehydroepiandrosterone (DHEA) is an androgenic intermediate metabolite produced by the adrenals and known as an Anti-Aging hormone with an improving effect on insulin resistance, an antioxidant effect, and an antifibrotic effect. Serum dehydroepiandrosterone sulfate (DHEA-s) has been shown to present low levels in advanced stages of NAFLD and diminished DHEA may contribute to progression of NAFLD. Growth hormone (GH) plays a crucial role not only in childhood growth but also in adult metabolic regulation, and adult GH deficiency (GHD) leads to increased visceral fat, dyslipidemia, and decreased QOL. Complicating NAFLD/NASH is a frequent occurrence in adult GHD and is improved by GH replacement therapy. On this basis, aging is an important risk factor for progression of NASH, which suggests a need for discussion of NASH and NAFLD from the perspective of Anti-Aging Medicine.
{"title":"Science of Nonalcoholic Fatty Liver Disease in Anti-Aging Medicine 2011","authors":"Y. Sumida, Y. Naito, E. Hashimoto, W. Aoi, Yutaka Takahashi, Y. Yonei, T. Yoshikawa","doi":"10.3793/JAAM.9.24","DOIUrl":"https://doi.org/10.3793/JAAM.9.24","url":null,"abstract":"Nonalcoholic fatty liver disease (NAFLD) is a chronic liver disease caused primarily by obesity, and its incidence among Japanese adults is rapidly rising at 10-40%. Most NAFLD presents as simple steatosis, but some are nonalcoholic steatohepatitis (NASH) progressing to hepatic cirrhosis or hepatocellular carcinoma. NAFLD is diagnosed by the following three features; (1) alcohol non-consumers (“non-drinkers”), (2) steatosis, and (3) exclusion of liver disease caused by other factors, with non-drinkers including light consumers of alcohol in amounts not engendering alcoholic liver disease. Dietary treatment is the basis of therapy, but evidence concerning exercise therapy has accumulated recently, and its mechanisms have been explained. Dehydroepiandrosterone (DHEA) is an androgenic intermediate metabolite produced by the adrenals and known as an Anti-Aging hormone with an improving effect on insulin resistance, an antioxidant effect, and an antifibrotic effect. Serum dehydroepiandrosterone sulfate (DHEA-s) has been shown to present low levels in advanced stages of NAFLD and diminished DHEA may contribute to progression of NAFLD. Growth hormone (GH) plays a crucial role not only in childhood growth but also in adult metabolic regulation, and adult GH deficiency (GHD) leads to increased visceral fat, dyslipidemia, and decreased QOL. Complicating NAFLD/NASH is a frequent occurrence in adult GHD and is improved by GH replacement therapy. On this basis, aging is an important risk factor for progression of NASH, which suggests a need for discussion of NASH and NAFLD from the perspective of Anti-Aging Medicine.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"30 1","pages":"24-33"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74552251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
As the aging population expands rapidly worldwide, it has become increasingly important to identify factors that offer means to promote healthy aging. It is well documented that advancing age is associated with increased body fat and blunted insulin action. Centenarians, who are the best model of successful aging, are a unique exception to this phenomenon. Increasing evidence has documented the preservation of insulin sensitivity and glucose homeostasis along with the very low prevalence of metabolic syndrome, diabetes, and cardiovascular disease among centenarians. We demonstrated that centenarians have a high serum concentration of adiponectin, which was associated with a favorable metabolic phenotype, including higher levels of HDL-C and lipoprotein lipase, and lower levels of hemoglobin A1c, C-reactive protein, and E-selectin concentrations. These observations suggested that high adiponectin concentration may be potentially important for maintaining health and function and could be a target for Anti-Aging Medicine.
{"title":"Adiponectin and Healthy Aging in Centenarians","authors":"Y. Arai, N. Hirose","doi":"10.3793/JAAM.9.1","DOIUrl":"https://doi.org/10.3793/JAAM.9.1","url":null,"abstract":"As the aging population expands rapidly worldwide, it has become increasingly important to identify factors that offer means to promote healthy aging. It is well documented that advancing age is associated with increased body fat and blunted insulin action. Centenarians, who are the best model of successful aging, are a unique exception to this phenomenon. Increasing evidence has documented the preservation of insulin sensitivity and glucose homeostasis along with the very low prevalence of metabolic syndrome, diabetes, and cardiovascular disease among centenarians. We demonstrated that centenarians have a high serum concentration of adiponectin, which was associated with a favorable metabolic phenotype, including higher levels of HDL-C and lipoprotein lipase, and lower levels of hemoglobin A1c, C-reactive protein, and E-selectin concentrations. These observations suggested that high adiponectin concentration may be potentially important for maintaining health and function and could be a target for Anti-Aging Medicine.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"7 1","pages":"1-5"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79956951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Given that ovarian function declines with age, older women occasionally experience health or fertility problems. Functional change is influenced by physical, mental, oxidative, and glycation stresses, which may lead to a decline in the secretion of hormones, such as melatonin, growth hormone/insulin-like growth factor-I, and dehydroepiandrosterone (DHEA). Many different factors influence the degradation of ovarian function, and the proper treatment depends on the accurate identification of each patient’s condition. Potential degradation mechanisms include the accumulation of advanced glycation end products (AGEs) by glycation stress, and the activation of receptors for AGEs. Accumulated evidence has suggested that in vitro fertilization success rate can be increased on administration of melatonin and DHEA, or glycation stress therapy, to patients with poor ovarian function. The provision of advanced medical technology to rejuvenate ovarian function should be combined with prophylactic lifestyle guidance, such as that developed by Anti-Aging Medicine, to treat the underlying causes of ovarian functional decline. Here, we review the application of Anti-Aging Medicine to aspects of reproductive medicine.
{"title":"Anti-Aging Medicine and Reproductive Health","authors":"M. Jinno, H. Tamura, Y. Yonei","doi":"10.3793/JAAM.9.6","DOIUrl":"https://doi.org/10.3793/JAAM.9.6","url":null,"abstract":"Given that ovarian function declines with age, older women occasionally experience health or fertility problems. Functional change is influenced by physical, mental, oxidative, and glycation stresses, which may lead to a decline in the secretion of hormones, such as melatonin, growth hormone/insulin-like growth factor-I, and dehydroepiandrosterone (DHEA). Many different factors influence the degradation of ovarian function, and the proper treatment depends on the accurate identification of each patient’s condition. Potential degradation mechanisms include the accumulation of advanced glycation end products (AGEs) by glycation stress, and the activation of receptors for AGEs. Accumulated evidence has suggested that in vitro fertilization success rate can be increased on administration of melatonin and DHEA, or glycation stress therapy, to patients with poor ovarian function. The provision of advanced medical technology to rejuvenate ovarian function should be combined with prophylactic lifestyle guidance, such as that developed by Anti-Aging Medicine, to treat the underlying causes of ovarian functional decline. Here, we review the application of Anti-Aging Medicine to aspects of reproductive medicine.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"87 1","pages":"6-13"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75847961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
N. Kanamura, T. Amemiya, Toshiro Yamamoto, K. Mishima, M. Saito, T. Tsuji, Takahiro Nakamura
Anti-Aging Medicine is a theoretical and practical science which aims to ensure the achievement of a long and healthy life. Dental medicine plays an important role in its practice. Given the substantial influence of dental/oral diseases on general health, the maintenance and improvement of oral function promotes not only dental/oral Anti-Aging but also systemic Anti-Aging as well.The current target of Anti-Aging dental medicine is the prevention or slowing down of the age-related decline in oral function by evaluating indicators of oral function, such as dental age, periodontal age, occlusion age, swallowing age, and salivary age. In this symposium, Dr. Kenji Mishima (Department of Dentistry, Tsurumi University), speaking on “Application of Cell Transplantation Therapy to Salivary Gland Dysfunction”, Dr. Masahiro Saito (Research Institute for Science and Technology, Tokyo University of Science), speaking on “Role of Tooth Regeneration in Anti-Aging Medicine” and myself, Dr. Narisato Kanemura (Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine), speaking on “Development of a New Periodontal Tissue Regeneration Method Aimed at Anti-Aging Use”, delivered presentations about the current status and future prospects of regenerative dentistry, which aims not only to prevent a decrease in oral function but also to restore it when function is lost, and introduced the latest in regenerative dentistry involving the salivary glands, teeth, oral mucosal epithelia, and periodontal ligaments. In addition, to describe collaboration between dental medicine and ophthalmology, Dr. Takahiro Nakamura (Faculty of Life and Medical Sciences, Doshisha University), speaking on “Current Status and Future Prospects of Corneal Regenerative Therapy using Oral Tissue”, introduced the current status and future prospects of corneal regenerative therapy using periodontal mucosal epithelium. Summaries of these lectures are presented here. In the “Dental Regenerative Therapy using Oral Tissues” symposium at the 2011 11th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, the experts were invited to report recent findings on maintenance.
{"title":"Dental Regenerative Therapy using Oral Tissues","authors":"N. Kanamura, T. Amemiya, Toshiro Yamamoto, K. Mishima, M. Saito, T. Tsuji, Takahiro Nakamura","doi":"10.3793/JAAM.9.14","DOIUrl":"https://doi.org/10.3793/JAAM.9.14","url":null,"abstract":"Anti-Aging Medicine is a theoretical and practical science which aims to ensure the achievement of a long and healthy life. Dental medicine plays an important role in its practice. Given the substantial influence of dental/oral diseases on general health, the maintenance and improvement of oral function promotes not only dental/oral Anti-Aging but also systemic Anti-Aging as well.The current target of Anti-Aging dental medicine is the prevention or slowing down of the age-related decline in oral function by evaluating indicators of oral function, such as dental age, periodontal age, occlusion age, swallowing age, and salivary age. In this symposium, Dr. Kenji Mishima (Department of Dentistry, Tsurumi University), speaking on “Application of Cell Transplantation Therapy to Salivary Gland Dysfunction”, Dr. Masahiro Saito (Research Institute for Science and Technology, Tokyo University of Science), speaking on “Role of Tooth Regeneration in Anti-Aging Medicine” and myself, Dr. Narisato Kanemura (Dental Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine), speaking on “Development of a New Periodontal Tissue Regeneration Method Aimed at Anti-Aging Use”, delivered presentations about the current status and future prospects of regenerative dentistry, which aims not only to prevent a decrease in oral function but also to restore it when function is lost, and introduced the latest in regenerative dentistry involving the salivary glands, teeth, oral mucosal epithelia, and periodontal ligaments. In addition, to describe collaboration between dental medicine and ophthalmology, Dr. Takahiro Nakamura (Faculty of Life and Medical Sciences, Doshisha University), speaking on “Current Status and Future Prospects of Corneal Regenerative Therapy using Oral Tissue”, introduced the current status and future prospects of corneal regenerative therapy using periodontal mucosal epithelium. Summaries of these lectures are presented here. In the “Dental Regenerative Therapy using Oral Tissues” symposium at the 2011 11th Scientific Meeting of the Japanese Society of Anti-Aging Medicine, the experts were invited to report recent findings on maintenance.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"128 1","pages":"14-23"},"PeriodicalIF":0.0,"publicationDate":"2012-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79560507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Ichihashi, Ikuyo Yoshida, Hiroshi Yamaguchi, K. Yamashita, Tstsuo Akiba
We conducted a 24-week clinical study in 20 women with skin and scalp hair problems (e.g., skin dryness, pigmented spots, roughness, thinning hair, and hair loss) and symptoms of ketsuo or kekkyo to investigate the effects of kamishoyosangoshimotsuto extract (KGS1) on skin condition and hair properties. Skin evaluation revealed significant improvements in stratum corneum moisture content, skin texture score, and spot brightness. Hair evaluation showed significant increases in hair thickness and hair breakage strength. Furthermore, we visually analyzed the effects of KGS1 on skin condition using facial photographs taken before and after test product treatment. In almost half of subjects, facial color and the skin color of spots were visibly brightened, skin dullness was improved, and skin luster was increased.
{"title":"KGS1 Kamishoyosangoshimotsuto Extract Tablets Improved Skin Condition and Hair Properties","authors":"M. Ichihashi, Ikuyo Yoshida, Hiroshi Yamaguchi, K. Yamashita, Tstsuo Akiba","doi":"10.3793/JAAM.8.15","DOIUrl":"https://doi.org/10.3793/JAAM.8.15","url":null,"abstract":"We conducted a 24-week clinical study in 20 women with skin and scalp hair problems (e.g., skin dryness, pigmented spots, roughness, thinning hair, and hair loss) and symptoms of ketsuo or kekkyo to investigate the effects of kamishoyosangoshimotsuto extract (KGS1) on skin condition and hair properties. Skin evaluation revealed significant improvements in stratum corneum moisture content, skin texture score, and spot brightness. Hair evaluation showed significant increases in hair thickness and hair breakage strength. Furthermore, we visually analyzed the effects of KGS1 on skin condition using facial photographs taken before and after test product treatment. In almost half of subjects, facial color and the skin color of spots were visibly brightened, skin dullness was improved, and skin luster was increased.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"29 1","pages":"15-22"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90108604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Narukawa, Y. Anzai, T. Murakami, R. Isogai, Nakagawa Sonoko, Hidekazu Yamada
Objective: The objective of this study was to identify the optimal BMI and desirable dietary habits for reducing oxidative stress and thereby slowing aging and preventing chronic diseases. We examined the relationships between urinary 8-hydroxydeoxyguanosine (8-OHdG) and F2-isoprostane excretions with BMI, dietary intakes and serum antioxidant vitamin concentrations. Method: The subjects were 15 people undergoing an Anti-Aging checkup (average age 64.9 [42-79], average BMI 23.2[16.0-31.6]).Exclusion criteria included a history of cancer, cardiovascular disease, stroke, diabetes, and current smoking. The serum parameters examined were α-carotene, β-carotene, vitamin C and vitamin E, the urinary parameters were 8-OHdG and F2-isoprostane and the dietary intake parameters were energy, carbohydrate, fat, protein, α-carotene, β-carotene, vitamin C, vitamin E and fruit and vegetable. Results: The relationships between urinary 8-OHdG and F2-isoprostane excretions and BMI both followed a quadratic curve with the lowest levels at BMI 23 (8-OHdG: R²= 0.749, F2-isoprostane: R² = 0.519). Multiple linear regression analysis showed that important variation factors for urinary 8-OHdG excretion were BMI and carbohydrate/energy ratio (R²= 0.826). Important variation factors for urinary F2-isoprostane excretion were BMI and serum vitamin E concentration (R²=0.613). Conclusion: The relationships between urinary 8-OHdG and F2-isoprostane excretions and BMI both followed a U-shaped curve with the lowest levels at BMI 23.
{"title":"Effects of Body Mass Index (BMI), Dietary Intake and Serum Antioxidant Vitamin Concentration on Urinary 8-hydroxydeoxyguanosine and F2-isoprostane Excretions","authors":"T. Narukawa, Y. Anzai, T. Murakami, R. Isogai, Nakagawa Sonoko, Hidekazu Yamada","doi":"10.3793/JAAM.8.1","DOIUrl":"https://doi.org/10.3793/JAAM.8.1","url":null,"abstract":"Objective: The objective of this study was to identify the optimal BMI and desirable dietary habits for reducing oxidative stress and thereby slowing aging and preventing chronic diseases. We examined the relationships between urinary 8-hydroxydeoxyguanosine (8-OHdG) and F2-isoprostane excretions with BMI, dietary intakes and serum antioxidant vitamin concentrations. Method: The subjects were 15 people undergoing an Anti-Aging checkup (average age 64.9 [42-79], average BMI 23.2[16.0-31.6]).Exclusion criteria included a history of cancer, cardiovascular disease, stroke, diabetes, and current smoking. The serum parameters examined were α-carotene, β-carotene, vitamin C and vitamin E, the urinary parameters were 8-OHdG and F2-isoprostane and the dietary intake parameters were energy, carbohydrate, fat, protein, α-carotene, β-carotene, vitamin C, vitamin E and fruit and vegetable. Results: The relationships between urinary 8-OHdG and F2-isoprostane excretions and BMI both followed a quadratic curve with the lowest levels at BMI 23 (8-OHdG: R²= 0.749, F2-isoprostane: R² = 0.519). Multiple linear regression analysis showed that important variation factors for urinary 8-OHdG excretion were BMI and carbohydrate/energy ratio (R²= 0.826). Important variation factors for urinary F2-isoprostane excretion were BMI and serum vitamin E concentration (R²=0.613). Conclusion: The relationships between urinary 8-OHdG and F2-isoprostane excretions and BMI both followed a U-shaped curve with the lowest levels at BMI 23.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"19 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86199019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: As the concentrations of some hormones are known to decrease with age, the aim of the present study was to develop a method to predict the functional age of the endocrine system.Methods: We retrospectively examined data for blood serum or plasma hormone concentration from 3,313 healthy Japanese (2,006 men and 1,307 women, aged 40-79 years) who gave blood samples between 2005 and 2009. Data for DHEA-s, insulin-like growth factor (IGF-I), cortisol, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were analyzed, and the correlation between concentration of each hormone and age was calculated. In a second stage, data were grouped in 10-year age intervals, subjected to one-way analysis of variance (ANOVA) and evaluated using Tukey’s post-hoc test.Results: In both men and women, TSH was positively correlated with age. IGF-I, DHEA-s and cortisol were negatively correlated with age; in men, age was negatively correlated with FT3. Although correlation coefficients (r) and significance levels differed between sexes and hormones, DHEA-s concentration was highly correlated with age and declined with age in both men and women. An age-structured model was developed from the regression of mean DHEA-s concentration and median age of each group. The confidence limits for the regression were small and imply that the predictions from the model are accurate.Conclusion: We developed an age-structured model of age related to serum DHEA-s concentration. It may be useful as an index for evaluating the functional age of the endocrine system in Japanese men and women.
{"title":"Development of a Model of Functional Endocrine Age in Japanese People","authors":"K. Nomoto, S. Arita, Y. Yonei","doi":"10.3793/JAAM.8.69","DOIUrl":"https://doi.org/10.3793/JAAM.8.69","url":null,"abstract":"Objective: As the concentrations of some hormones are known to decrease with age, the aim of the present study was to develop a method to predict the functional age of the endocrine system.Methods: We retrospectively examined data for blood serum or plasma hormone concentration from 3,313 healthy Japanese (2,006 men and 1,307 women, aged 40-79 years) who gave blood samples between 2005 and 2009. Data for DHEA-s, insulin-like growth factor (IGF-I), cortisol, thyroid-stimulating hormone (TSH), free triiodothyronine (FT3) and free thyroxine (FT4) were analyzed, and the correlation between concentration of each hormone and age was calculated. In a second stage, data were grouped in 10-year age intervals, subjected to one-way analysis of variance (ANOVA) and evaluated using Tukey’s post-hoc test.Results: In both men and women, TSH was positively correlated with age. IGF-I, DHEA-s and cortisol were negatively correlated with age; in men, age was negatively correlated with FT3. Although correlation coefficients (r) and significance levels differed between sexes and hormones, DHEA-s concentration was highly correlated with age and declined with age in both men and women. An age-structured model was developed from the regression of mean DHEA-s concentration and median age of each group. The confidence limits for the regression were small and imply that the predictions from the model are accurate.Conclusion: We developed an age-structured model of age related to serum DHEA-s concentration. It may be useful as an index for evaluating the functional age of the endocrine system in Japanese men and women.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"18 1","pages":"69-74"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87172162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antioxidants are known to prevent oxidative damage in cells caused by radiation. We have previously reported that whole-body irradiation with low doses of gamma rays to mice elevates the antioxidant thioredoxin-1 (Trx-1) levels in several organs. Furthermore, gamma ray irradiation also causes ATP release from the exposed cells. Extracellular ATP release in response to various stimuli has been reported to regulate the expression of intracellular antioxidants through activation of purinergic P2 receptors. Here, we review the relation between gamma-radiation-induced ATP release and the induction of cellular Trx-1 via purinergic signaling. Irradiation with gamma rays or exogenously adding ATP cause an increase in Trx-1 expression, and these phenomena disappear in the presence of an ecto-nucleotidase. Further, it is revealed that ATP generates intracellular reactive oxygen species (ROS), and thereby increases Trx-1 expression as an adaptive response to ROS. These findings suggest that gamma-radiation-induced release of extracellular ATP may contribute to the production of ROS via purinergic signaling, thereby leading to the promotion of intracellular antioxidants in response to an oxidative stress.
{"title":"ATP Released from Low-dose Gamma Ray-irradiated Cells Activates Intracellular Antioxidant Systems via Purine Receptors","authors":"S. Kojima, Erina Takai, Mitsutoshi Tsukimoto","doi":"10.3793/JAAM.8.108","DOIUrl":"https://doi.org/10.3793/JAAM.8.108","url":null,"abstract":"Antioxidants are known to prevent oxidative damage in cells caused by radiation. We have previously reported that whole-body irradiation with low doses of gamma rays to mice elevates the antioxidant thioredoxin-1 (Trx-1) levels in several organs. Furthermore, gamma ray irradiation also causes ATP release from the exposed cells. Extracellular ATP release in response to various stimuli has been reported to regulate the expression of intracellular antioxidants through activation of purinergic P2 receptors. Here, we review the relation between gamma-radiation-induced ATP release and the induction of cellular Trx-1 via purinergic signaling. Irradiation with gamma rays or exogenously adding ATP cause an increase in Trx-1 expression, and these phenomena disappear in the presence of an ecto-nucleotidase. Further, it is revealed that ATP generates intracellular reactive oxygen species (ROS), and thereby increases Trx-1 expression as an adaptive response to ROS. These findings suggest that gamma-radiation-induced release of extracellular ATP may contribute to the production of ROS via purinergic signaling, thereby leading to the promotion of intracellular antioxidants in response to an oxidative stress.","PeriodicalId":86085,"journal":{"name":"Journal of anti-aging medicine","volume":"23 1","pages":"108-113"},"PeriodicalIF":0.0,"publicationDate":"2011-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86502127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：