C. Teixeira, Nuno F S Pinto, David M. Pereira, R. Pereira, M. J. Fernandes, E. M. Castanheira, A. Fortes, M. S. Gonçalves
{"title":"Cytotoxicity Studies of Eugenol Amino Alcohols Derivatives","authors":"C. Teixeira, Nuno F S Pinto, David M. Pereira, R. Pereira, M. J. Fernandes, E. M. Castanheira, A. Fortes, M. S. Gonçalves","doi":"10.3390/ecsoc-25-11689","DOIUrl":null,"url":null,"abstract":": Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β -amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modi-fications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the ob-tained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.","PeriodicalId":11441,"journal":{"name":"ECSOC-25","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ECSOC-25","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecsoc-25-11689","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
: Eugenol is a phenylpropanoid displaying a wide range of biological activities. In this study, the cytotoxic activity of various β -amino alcohols derivatives from eugenol was evaluated in AGS (gastric cancer) and A549 (lung cancer) cell lines. The results show that some structural modi-fications resulted in enhanced cytotoxic activity towards cancer cells. In addition, the activation of caspase-3 and hence apoptosis induced by these molecules, was also explored. Considering the ob-tained results, some structure/activity relationships can be drawn, which may guide future structural improvements for anticancer agents.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
