Non-Alcoholic Fatty Liver and Fatty Pancreas Diseases Associate with Acute Pancreatitis

Abstract

Objective: Fat accumulation in the liver and pancreas are clinical manifestations of metabolic syndrome and associated with inflammation. It was aimed to investigate the effects of the computed tomography (CT) estimated non-alcoholic fatty liver disease (NAFLD) and non-alcoholic fatty pancreas disease (NAFPD) on the development of acute pancreatitis in this study. Patients and methods: This retrospective and cross sectional study was consisted of 194 participants who admitted to the hospital with an abdominal pain complaint and undergone an abdominal CT scan during the investigation of the differential diagnosis. Medical database records of patients were investigated. Groups were consisted of according to the presence of acute pancreatitis as study and control. Attenuation measurements of liver and pancreas were determined according to abdominal CT. Results: A statistical significance was observed for the development of acute pancreatitis when patients with normoglycemia were compared to both patients with prediabetes and diabetes. Percentages of NAFLD and NAFPD according to the median of CT attenuation difference between pancreas and spleen values were elevated in the study group. A logistic regression model was revealed that prediabetes, type 2 diabetes, NAFLD and NAFPD according to median value were risk factors for the acute pancreatitis (p