Yeme ile ilgili davranışlar genetik, çevre, duygusal durum, sosyodemografik özellikler, dini ve kültürel inançlar, medya, beden algısı gibi pek çok faktörden etkilenmektedir. Belirtildiği gibi birçok faktörden etkilenen yeme davranışının heyecan, can sıkıntısı, mutluluk, stres gibi duygusal faktörlerle yakından ilişkili olduğu görülmektedir. Günümüzde sağlıksız yeme davranışlarının yerine sağlıklı yeme davranışlarının oluşmasını sağlamada sezgisel yeme becerisinin gelişmesinin önemi üzerinde durulmakta ve sezgisel yemenin müdahale tekniği olarak kullanılması önemsenmektedir. Sezgisel yemenin, yeme bozukluklarının önlenmesinde, tedavisinde ve vücut ağırlığı yönetiminde kalori kısıtlı diyetlerin alternatifi olabileceği, ayrıca geleneksel yöntemlerle birlikte kullanılabileceği düşünülmektedir. Bu derlemede, sezgisel yeme kavramı ve bu kavramın vücut ağırlığı ve yeme bozuklukları üzerindeki etkisi hakkında literatür bilgileri sunulacaktır.
{"title":"SEZGİSEL YEME NEDİR?: BİR GÖZDEN GEÇİRME","authors":"Didem Bostan Bendaş, Çiçek Hocaoğlu","doi":"10.7197/cmj.1441696","DOIUrl":"https://doi.org/10.7197/cmj.1441696","url":null,"abstract":"Yeme ile ilgili davranışlar genetik, çevre, duygusal durum, sosyodemografik özellikler, dini ve kültürel inançlar, medya, beden algısı gibi pek çok faktörden etkilenmektedir. Belirtildiği gibi birçok faktörden etkilenen yeme davranışının heyecan, can sıkıntısı, mutluluk, stres gibi duygusal faktörlerle yakından ilişkili olduğu görülmektedir. Günümüzde sağlıksız yeme davranışlarının yerine sağlıklı yeme davranışlarının oluşmasını sağlamada sezgisel yeme becerisinin gelişmesinin önemi üzerinde durulmakta ve sezgisel yemenin müdahale tekniği olarak kullanılması önemsenmektedir. Sezgisel yemenin, yeme bozukluklarının önlenmesinde, tedavisinde ve vücut ağırlığı yönetiminde kalori kısıtlı diyetlerin alternatifi olabileceği, ayrıca geleneksel yöntemlerle birlikte kullanılabileceği düşünülmektedir. Bu derlemede, sezgisel yeme kavramı ve bu kavramın vücut ağırlığı ve yeme bozuklukları üzerindeki etkisi hakkında literatür bilgileri sunulacaktır.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"41 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140376924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anterior servikal korpektomi, servikal myelopatik spondilopatinin cerrahi tedavisinde spinal kordun dekompresyonunu sağlamak için kullanılan yaygın bir omurga cerrahisi prosedürüdür. Bu çalışmanın amacı bir ve iki seviye anterior servikal korpektominin klinik,radyolojik sonuçlarını ve komplikasyonlarını araştırmaktır. 2006 -2022 yılları arasında bir ve iki seviyeli anterior servikal korpektomi cerrahisi uygulanan servikal spondilotik myelopati hastaları rekrospektif olarak değerlendirmeye alınmıştır. Birincil olarak vakaların sonuçları klinik olarak vizüel analog skala (VAS) ile ölçülen boyun ağrısı ile, radyolojik olarak sagittal c2-c7 ve T1 slope açısı üzerinden değerlendirilmiştir. İkincil olarak sonuçlar komplikasyonlar ve füzyon açısından değerlendirilmiştir. Bir seviyeli korpektomi grubunda 16, iki seviyeli korpektomi grubunda 9 hasta yer aldı ve toplam 25 hastaya anterior servikal korpektomi uygulanmıştır. Her iki grubun postoperatif vas değerleri preoperatife göre anlamlı derecede azalmıştır. (p=0,001; p0,05) İki seviye grubundaki olguların ameliyat süresi, bir seviye grubundan istatistiksel olarak anlamlı düzeyde uzun saptanmıştır (p=0,007; p
{"title":"Anterior One- and Two-Level Cervical Corpectomy and Fusion for Cervical Spondylotic Myelopathy: A Retrospective Study","authors":"Huseyin Dogu","doi":"10.7197/cmj.1409049","DOIUrl":"https://doi.org/10.7197/cmj.1409049","url":null,"abstract":"Anterior servikal korpektomi, servikal myelopatik spondilopatinin cerrahi tedavisinde spinal kordun dekompresyonunu sağlamak için kullanılan yaygın bir omurga cerrahisi prosedürüdür. Bu çalışmanın amacı bir ve iki seviye anterior servikal korpektominin klinik,radyolojik sonuçlarını ve komplikasyonlarını araştırmaktır. \u00002006 -2022 yılları arasında bir ve iki seviyeli anterior servikal korpektomi cerrahisi uygulanan servikal spondilotik myelopati hastaları rekrospektif olarak değerlendirmeye alınmıştır. Birincil olarak vakaların sonuçları klinik olarak vizüel analog skala (VAS) ile ölçülen boyun ağrısı ile, radyolojik olarak sagittal c2-c7 ve T1 slope açısı üzerinden değerlendirilmiştir. İkincil olarak sonuçlar komplikasyonlar ve füzyon açısından değerlendirilmiştir. \u0000Bir seviyeli korpektomi grubunda 16, iki seviyeli korpektomi grubunda 9 hasta yer aldı ve toplam 25 hastaya anterior servikal korpektomi uygulanmıştır. Her iki grubun postoperatif vas değerleri preoperatife göre anlamlı derecede azalmıştır. (p=0,001; p0,05) İki seviye grubundaki olguların ameliyat süresi, bir seviye grubundan istatistiksel olarak anlamlı düzeyde uzun saptanmıştır (p=0,007; p","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"122 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140378648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hüsnü Çağrı Genç, Hakkı Çoşkun, Yıldırımcan Demirtaş, S. Soylu, Atilla Kurt
Aim: we aim to present the outcomes of the Laser Hemorrhoidoplasty (LHP) procedure performed in our clinic. Material and methods: In this retrospective study, we analyzed the outcomes of LHP performed on 112 patients in our clinic over a 24-month period. Patients were scheduled for follow-up visits at three weeks post-surgery, followed by subsequent follow-ups at three and six-month intervals. Results: Of the 112 patients, 73 (65.17%) were male, and 39 (34.82%) were female. The mean age was 52.6 years (range: 20-65). The mean operation duration was 18.3 minutes (range: 12-25). Seventy patients were classified as grade 2, while 42 patients were classified as grade 3. The mean hospital stay was 1.16 days. Among the 70 patients with grade 2 hemorrhoids, 5 were lost to follow-up, while 24 were followed up at 6 months and 41 at 1 year. One (1.42%) patient who attended the 1-year follow-up showed recurrence. Four patients (9.52%) showed recurrence. One patient with grade 3 hemorrhoids experienced postoperative bleeding lasting one week, requiring erythrocyte suspension replacement. Another patient with grade 3 hemorrhoids developed a hematoma, which resolved with conservative treatment. Eight patients (7.14%) with grade 3 hemorrhoids developed postoperative edema, all of whom improved with conservative treatment. Pain, evaluated using the Visual Analog Scale, was measured as 2.03 on the first postoperative day and 1.49 on the second postoperative day. Conclusion: LH treatment has been found to be a successful alternative treatment option for Grade 2 and Grade 3 diseases. It is emphasized that patient selection is crucial in LH treatment.
{"title":"Our Clinic's Experience with Laser Hemorrhoidoplasty.","authors":"Hüsnü Çağrı Genç, Hakkı Çoşkun, Yıldırımcan Demirtaş, S. Soylu, Atilla Kurt","doi":"10.7197/cmj.1446187","DOIUrl":"https://doi.org/10.7197/cmj.1446187","url":null,"abstract":"Aim: we aim to present the outcomes of the Laser Hemorrhoidoplasty (LHP) procedure performed in our clinic. \u0000Material and methods: In this retrospective study, we analyzed the outcomes of LHP performed on 112 patients in our clinic over a 24-month period. Patients were scheduled for follow-up visits at three weeks post-surgery, followed by subsequent follow-ups at three and six-month intervals. \u0000Results: Of the 112 patients, 73 (65.17%) were male, and 39 (34.82%) were female. The mean age was 52.6 years (range: 20-65). The mean operation duration was 18.3 minutes (range: 12-25). Seventy patients were classified as grade 2, while 42 patients were classified as grade 3. The mean hospital stay was 1.16 days. Among the 70 patients with grade 2 hemorrhoids, 5 were lost to follow-up, while 24 were followed up at 6 months and 41 at 1 year. One (1.42%) patient who attended the 1-year follow-up showed recurrence. Four patients (9.52%) showed recurrence. One patient with grade 3 hemorrhoids experienced postoperative bleeding lasting one week, requiring erythrocyte suspension replacement. Another patient with grade 3 hemorrhoids developed a hematoma, which resolved with conservative treatment. Eight patients (7.14%) with grade 3 hemorrhoids developed postoperative edema, all of whom improved with conservative treatment. Pain, evaluated using the Visual Analog Scale, was measured as 2.03 on the first postoperative day and 1.49 on the second postoperative day. \u0000Conclusion: LH treatment has been found to be a successful alternative treatment option for Grade 2 and Grade 3 diseases. It is emphasized that patient selection is crucial in LH treatment.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":" 18","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nesibe Yıldız Bilge, Hatice Terzi, H. Doğan, Demet Kablan, M. Şencan
Multiple myeloma (MM) is a hematologic malignancy characterized by bone marrow infiltration of clonal plasma cells. Today, there is no treatment for obtaining a complete cycle for MM. IL-36 is a cytokine composed of three agonists named alpha, beta, and gamma. Its increase in inflammation has been proven in the literature. It is also reported that IL-17 plays a role in some rheumatologic and malignant diseases together with inflammation. The aim of the study is to figure out the roles, if any, of IL-36 and IL-17 in the pathogenesis of multiple myeloma depending on their known physiology and to contribute to the literature to find new treatment options. 33 newly diagnosed MM patients who had never received any treatment and 33 healthy volunteers were included in the study. Basic laboratory parameters and interleukin levels in myeloma patient group and healthy group were included in the study. In the study, it was found that IL-36 alpha, beta, gamma, and IL-17 levels were statistically significantly lower in the disease group when compared to the healthy group. A negative correlation was found between IL-17 measurement and beta-2 microglobulin. Therefore, it was thought that IL-17 may be a marker to predict prognosis. In conclusion, we think that IL-36 and IL-17 may play a role in the etiopathogenesis of myeloma and IL-36 alpha and IL-17 may be associated with prognosis. However, there is a need for more comprehensive studies.
{"title":"DETERMINATION OF SERUM INTERLEUKIN-36 ALPHA, BETA, GAMMA AND INTERLEUKIN-17 LEVELS IN PATIENTS WITH MULTIPLE MYELOMA","authors":"Nesibe Yıldız Bilge, Hatice Terzi, H. Doğan, Demet Kablan, M. Şencan","doi":"10.7197/cmj.1431762","DOIUrl":"https://doi.org/10.7197/cmj.1431762","url":null,"abstract":"Multiple myeloma (MM) is a hematologic malignancy characterized by bone marrow infiltration of clonal plasma cells. Today, there is no treatment for obtaining a complete cycle for MM. IL-36 is a cytokine composed of three agonists named alpha, beta, and gamma. Its increase in inflammation has been proven in the literature. It is also reported that IL-17 plays a role in some rheumatologic and malignant diseases together with inflammation. \u0000The aim of the study is to figure out the roles, if any, of IL-36 and IL-17 in the pathogenesis of multiple myeloma depending on their known physiology and to contribute to the literature to find new treatment options. \u000033 newly diagnosed MM patients who had never received any treatment and 33 healthy volunteers were included in the study. Basic laboratory parameters and interleukin levels in myeloma patient group and healthy group were included in the study. \u0000In the study, it was found that IL-36 alpha, beta, gamma, and IL-17 levels were statistically significantly lower in the disease group when compared to the healthy group. A negative correlation was found between IL-17 measurement and beta-2 microglobulin. Therefore, it was thought that IL-17 may be a marker to predict prognosis. \u0000In conclusion, we think that IL-36 and IL-17 may play a role in the etiopathogenesis of myeloma and IL-36 alpha and IL-17 may be associated with prognosis. However, there is a need for more comprehensive studies.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":" 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140386749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Far lateral lomber disk herniasyonları klinik, radyolojik ve cerrahi teknik açıdan kanal içi lomber disk herniasyonlarından farklıdır. Bu çalışmanın amacı, trans pars mikrocerrahi tekniği kullanılarak ameliyat edilen uzak lateral disk hernilerinin cerrahi ve nüks sonuçlarını sunmak ve nüks için risk faktörlerini belirlemektir. 2017-2022 yılları arası Atlas Üniversitesi Medicine Hastanesinde farlateral lomber disk herniasyonu tanısı ve transpars mikrodiskektomi cerrahisi ile tedavisi yapılan vakalar retroskopik olarak değerlendirildi. Bütün hastaların yaş cinsiyet ağrı özellikleri,nörolojik durumu ve radyolojik özellikleri ameliyat süreleri, ameliyat öncesi ve sonrası Vizuel Analog skala (VAS) skorları, ve Oswestry Engellilik İndeksi(ODİ) skorları ,ameliyat sonrası geç dönem MacNab memnuniyet oranları kaydedildi. Araştırma 58,2’si (n=53) erkek, %41,8’i (n=34) kadın olmak üzere toplam 91 olguyla yapılmıştır. Olguların yaşları 39 ile 86 arasında değişmekte olup; ortalaması 57,42±10,47’dir. Vakalarda %76,92 mükemmel (70 hasta), %16,48 iyi (15 hasta), %6,5 orta (6 hasta) sonuç elde edildi. Olguların %5,5’inde (n=5) nüks olduğu görülmüştür. Rekürren olguların cinsiyetleri, yaşları, tarafları, operasyon süreleri ve seviyeleri, istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05). Rekürren olguların preop ve postop VAS skorları, rekürren olmayan olgulardan istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05).Rekürren olguların preop ve postop ODİ skorları, rekürren olmayan olgulardan istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05). Far lateral lomber disk herniasyonlarının cerrahi tedavisinde uyguladığımız Mikrocerrahi ile transpars girişim güvenli ve etkin bir seçenektir. Rekürrens için yaş cinsiyet ,seviye,taraf,vas ve odi skorlarını risk faktörü olarak saptamadık.
远外侧腰椎间盘突出症与椎管内腰椎间盘突出症在临床、放射学和手术方面都有所不同。本研究旨在介绍采用经椎间隙显微外科技术对远外侧椎间盘突出症进行手术治疗和复发的结果，并找出复发的风险因素。对2017年至2022年间在阿特拉斯大学医学院附属医院确诊为远外侧腰椎间盘突出症并接受经旁路显微椎间盘切除手术治疗的病例进行了回顾性评估。研究记录了所有患者的年龄、性别、疼痛特征、神经状况、放射学特征、手术时间、术前和术后视觉模拟量表（VAS）评分、Oswestry残疾指数（ODI）评分以及术后晚期MacNab满意率。研究共涉及 91 名患者，其中男性占 58.2%（53 人），女性占 41.8%（34 人）。病例年龄在 39 至 86 岁之间，平均年龄为（57.42±10.47）岁。结果为：76.92%为优（70 名患者），16.48%为良（15 名患者），6.5%为一般（6 名患者）。复发率为 5.5%（5 例）。复发病例的性别、年龄、病侧、手术时间和复发程度在统计学上无显著差异（P>0.05）。复发病例的术前和术后 VAS 评分与非复发病例无明显统计学差异（P>0.05）；复发病例的术前和术后 ODI 评分与非复发病例无明显统计学差异（P>0.05）。显微外科转位手术是手术治疗远外侧腰椎间盘突出症的一种安全有效的方法。研究发现，年龄、性别、级别、侧位、Vas和odi评分均不是复发的风险因素。
{"title":"Surgical Outcomes and Recurrence Rates in Far Lateral Lumbar Disc Herniations: A Retrospective Analysis of 91 Cases","authors":"Huseyin Dogu","doi":"10.7197/cmj.1403570","DOIUrl":"https://doi.org/10.7197/cmj.1403570","url":null,"abstract":"Far lateral lomber disk herniasyonları klinik, radyolojik ve cerrahi teknik açıdan kanal içi lomber disk herniasyonlarından farklıdır. Bu çalışmanın amacı, trans pars mikrocerrahi tekniği kullanılarak ameliyat edilen uzak lateral disk hernilerinin cerrahi ve nüks sonuçlarını sunmak ve nüks için risk faktörlerini belirlemektir. \u00002017-2022 yılları arası Atlas Üniversitesi Medicine Hastanesinde farlateral lomber disk herniasyonu tanısı ve transpars mikrodiskektomi cerrahisi ile tedavisi yapılan vakalar retroskopik olarak değerlendirildi. Bütün hastaların yaş cinsiyet ağrı özellikleri,nörolojik durumu ve radyolojik özellikleri ameliyat süreleri, ameliyat öncesi ve sonrası Vizuel Analog skala (VAS) skorları, ve Oswestry Engellilik İndeksi(ODİ) skorları ,ameliyat sonrası geç dönem MacNab memnuniyet oranları kaydedildi. \u0000Araştırma 58,2’si (n=53) erkek, %41,8’i (n=34) kadın olmak üzere toplam 91 olguyla yapılmıştır. Olguların yaşları 39 ile 86 arasında değişmekte olup; ortalaması 57,42±10,47’dir. Vakalarda %76,92 mükemmel (70 hasta), %16,48 iyi (15 hasta), %6,5 orta (6 hasta) sonuç elde edildi. Olguların %5,5’inde (n=5) nüks olduğu görülmüştür. Rekürren olguların cinsiyetleri, yaşları, tarafları, operasyon süreleri ve seviyeleri, istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05). Rekürren olguların preop ve postop VAS skorları, rekürren olmayan olgulardan istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05).Rekürren olguların preop ve postop ODİ skorları, rekürren olmayan olgulardan istatistiksel olarak anlamlı farklılık göstermemektedir (p>0,05). \u0000Far lateral lomber disk herniasyonlarının cerrahi tedavisinde uyguladığımız Mikrocerrahi ile transpars girişim güvenli ve etkin bir seçenektir. Rekürrens için yaş cinsiyet ,seviye,taraf,vas ve odi skorlarını risk faktörü olarak saptamadık.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":" 9","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140387330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fatih Çubuk, Rukiye Aslan, M. Hasbek, Ayşe Hümeyra Taşkın Kafa
Objective: It was aimed to explore the correlation between demographic characteristics and the presence of comorbidity in the antibody response after the second dose of vaccination in healthcare workers in this study. In addition, the third and fourth dose approaches of the participants and the protection of the antibody levels formed by the two doses of vaccine against COVID-19 were examined observationally. Materials and Methods: Health workers, whose NCP and S protein antibody levels were detected on the 30th day after the second dose of the CoronaVac vaccine, were followed up in terms of being vaccinated for the third and fourth doses and having COVID-19. Results: Higher levels of S antibodies were detected in women after two doses of vaccination (p=0.001). It was pointed out that smoking has a negative effect on the antibody response after vaccination (p=0.008). People who had pre-vaccine COVID-19 had higher NCP antibody levels after two doses of vaccination (p=0.013). Of the participants, 152 (97.4%) were vaccinated with the third dose and 110 (70.5%) with the fourth dose. Conclusion: The antibody response after two doses of inactivated CoronaVac® vaccination probe is significantly higher in women, younger people, non-smokers, and people who have not been previously infected with the SARS-CoV-2.
{"title":"Evaluation of Antibody Response After COVID-19 Vaccination in Healthcare Workers: A Turkish Tertiary Hospital Experience","authors":"Fatih Çubuk, Rukiye Aslan, M. Hasbek, Ayşe Hümeyra Taşkın Kafa","doi":"10.7197/cmj.1382874","DOIUrl":"https://doi.org/10.7197/cmj.1382874","url":null,"abstract":"Objective: It was aimed to explore the correlation between demographic characteristics and the presence of comorbidity in the antibody response after the second dose of vaccination in healthcare workers in this study. In addition, the third and fourth dose approaches of the participants and the protection of the antibody levels formed by the two doses of vaccine against COVID-19 were examined observationally. \u0000Materials and Methods: Health workers, whose NCP and S protein antibody levels were detected on the 30th day after the second dose of the CoronaVac vaccine, were followed up in terms of being vaccinated for the third and fourth doses and having COVID-19. \u0000Results: Higher levels of S antibodies were detected in women after two doses of vaccination (p=0.001). It was pointed out that smoking has a negative effect on the antibody response after vaccination (p=0.008). People who had pre-vaccine COVID-19 had higher NCP antibody levels after two doses of vaccination (p=0.013). Of the participants, 152 (97.4%) were vaccinated with the third dose and 110 (70.5%) with the fourth dose. \u0000Conclusion: The antibody response after two doses of inactivated CoronaVac® vaccination probe is significantly higher in women, younger people, non-smokers, and people who have not been previously infected with the SARS-CoV-2.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":" 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140388760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Muhammed Faruk Aşkın, Şeyma Taştemur, M. A. Gedikli, Ferhan Candan, Yener Koc
One of the vital problems after earthquakes that caused many deaths and injuries is crush syndrome due to traumatic muscle damage. After the two earthquakes of 7.7 and 7.6 magnitude affecting 11 provinces with the epicentre in Kahramanmaraş on 6 February 2023, 319 patients over the age of 18 were admitted to Sivas Cumhuriyet University Research and Practice Hospital between 6-14 February. 87 of 319 patients received inpatient follow-up and treatment. The age, gender, duration of stay in the rubble, province of residence, operation performed, duration of hospital stay, amount of fluid given in the first 24 hours, amount of urine output in the first 24 hours, body trauma sites, some laboratory parameters at the time of admission and during follow-up were retrospectively evaluated from the hospital records of all 43 patients diagnosed with crush syndrome among the inpatients between 6-28 February. The age of the patients was 39±19.6 years, duration of stay under the cave-in (hours) 22.74±36.32, duration of hospitalization (days) 7.26±5.42, amount of fluid given in the first 24 hours (ml) 4954.18±3142, amount of urine output in the first 24 hours (ml) 2646.42±2262.65, admission creatinine (mg/dl) 1.59±2.25, admission creatine kinase (CK) (U/L) 11716.37±18520. 44.2% of the patients were female, 72.1% came from Kahramanmaraş province, 46.5% underwent surgical intervention, 67.4% had an admission CK above 1000 u/l, 14% received hemodialysis treatment, 46.5% had a duration of hospitalization shorter than 7 days to reach the CK reference range and 51.2% had a duration of hospitalization longer than 21 days. The effect of other parameters on the duration of hospitalization and the time to reach the reference range of CK and correlation with laboratory parameters were analysed. As a result, it is thought that the parameters affecting the time to reach the CK reference range and the duration of hospitalization can be used to calculate and reduce the duration of hospitalization in prospective crush syndrome cases.
{"title":"AFTER THE EARTHQUAKES WITH EPICENTER IN KAHRAMANMARAŞ ON FEBRUARY 6, 2023; CRUSH SYNDROME","authors":"Muhammed Faruk Aşkın, Şeyma Taştemur, M. A. Gedikli, Ferhan Candan, Yener Koc","doi":"10.7197/cmj.1351473","DOIUrl":"https://doi.org/10.7197/cmj.1351473","url":null,"abstract":"One of the vital problems after earthquakes that caused many deaths and injuries is crush syndrome due to traumatic muscle damage. \u0000After the two earthquakes of 7.7 and 7.6 magnitude affecting 11 provinces with the epicentre in Kahramanmaraş on 6 February 2023, 319 patients over the age of 18 were admitted to Sivas Cumhuriyet University Research and Practice Hospital between 6-14 February. 87 of 319 patients received inpatient follow-up and treatment. The age, gender, duration of stay in the rubble, province of residence, operation performed, duration of hospital stay, amount of fluid given in the first 24 hours, amount of urine output in the first 24 hours, body trauma sites, some laboratory parameters at the time of admission and during follow-up were retrospectively evaluated from the hospital records of all 43 patients diagnosed with crush syndrome among the inpatients between 6-28 February. \u0000The age of the patients was 39±19.6 years, duration of stay under the cave-in (hours) 22.74±36.32, duration of hospitalization (days) 7.26±5.42, amount of fluid given in the first 24 hours (ml) 4954.18±3142, amount of urine output in the first 24 hours (ml) 2646.42±2262.65, admission creatinine (mg/dl) 1.59±2.25, admission creatine kinase (CK) (U/L) 11716.37±18520. \u000044.2% of the patients were female, 72.1% came from Kahramanmaraş province, 46.5% underwent surgical intervention, 67.4% had an admission CK above 1000 u/l, 14% received hemodialysis treatment, 46.5% had a duration of hospitalization shorter than 7 days to reach the CK reference range and 51.2% had a duration of hospitalization longer than 21 days. \u0000The effect of other parameters on the duration of hospitalization and the time to reach the reference range of CK and correlation with laboratory parameters were analysed. \u0000As a result, it is thought that the parameters affecting the time to reach the CK reference range and the duration of hospitalization can be used to calculate and reduce the duration of hospitalization in prospective crush syndrome cases.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140389595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Multiple sclerosis (MS) is a chronic disease that affects the central nervous system in primarily young adults. Although the exact etiology of MS is unknown, autoimmune mechanisms are thought to play a crucial role, especially with CD4+ T cells involved in the immune response. Inflammatory reactions involving T cells and macrophages are commonly observed in MS lesions. B lymphocytes, plasma cells, and antibodies also contribute to MS pathogenesis. Neutrophils, lymphocytes, monocytes, and platelets, key immune system components, play roles in inflammatory processes, but their association with MS prognosis remains inconclusive. Due to its heterogeneous nature, clinical manifestations of MS vary depending on the location of the affected central nervous system. While several potential biomarkers have been identified for MS diagnosis and monitoring, none have been universally accepted. Studies have examined complete blood count parameters in MS patients, including erythrocyte, platelet, and leukocyte populations. Changes in these parameters have been observed in MS patients compared to healthy controls and may be related to disease prognosis. For example, increased erythrocyte fragility and altered hemoglobin levels have been reported in MS patients. Leukocyte counts and ratios, such as the neutrophil/lymphocyte ratio, have shown associations with disease severity. Platelet activation and interaction with immune cells have also been implicated in MS pathophysiology. Nevertheless, further research is needed to fully understand the role of complete blood count parameters in MS. Identifying reliable biomarkers for early diagnosis and prognosis prediction would greatly enhance MS management. Moreover, these benefits could lead to substantial improvements in achieving complete recovery of patients, surpassing the focus on current symptomatic treatments.
多发性硬化症（MS）是一种主要影响青壮年中枢神经系统的慢性疾病。虽然多发性硬化症的确切病因尚不清楚，但人们认为自身免疫机制在其中发挥了关键作用，尤其是 CD4+ T 细胞参与了免疫反应。在多发性硬化症的病变中经常可以观察到涉及 T 细胞和巨噬细胞的炎症反应。B 淋巴细胞、浆细胞和抗体也是多发性硬化症的发病机制之一。中性粒细胞、淋巴细胞、单核细胞和血小板是免疫系统的关键组成部分，在炎症过程中发挥作用，但它们与多发性硬化症预后的关系仍无定论。由于多发性硬化症具有异质性，其临床表现因受累中枢神经系统的位置而异。虽然已经发现了几种用于多发性硬化症诊断和监测的潜在生物标志物，但还没有一种得到普遍认可。研究已经检测了多发性硬化症患者的全血细胞计数参数，包括红细胞、血小板和白细胞数量。与健康对照组相比，在多发性硬化症患者中观察到了这些参数的变化，这些变化可能与疾病的预后有关。例如，有报道称多发性硬化症患者的红细胞脆性增加，血红蛋白水平改变。白细胞计数和比率（如中性粒细胞/淋巴细胞比率）与疾病的严重程度有关。血小板活化和与免疫细胞的相互作用也与多发性硬化症的病理生理学有关。然而，要全面了解全血细胞计数参数在多发性硬化症中的作用，还需要进一步的研究。确定用于早期诊断和预后预测的可靠生物标志物将大大提高多发性硬化症的治疗效果。此外，这些益处还能大大改善患者的完全康复，超越目前对症治疗的关注。
{"title":"Complete Blood Count in Multiple Sclerosis","authors":"S. Bolat, Demet Kablan","doi":"10.7197/cmj.1369992","DOIUrl":"https://doi.org/10.7197/cmj.1369992","url":null,"abstract":"Multiple sclerosis (MS) is a chronic disease that affects the central nervous system in primarily young adults. Although the exact etiology of MS is unknown, autoimmune mechanisms are thought to play a crucial role, especially with CD4+ T cells involved in the immune response. Inflammatory reactions involving T cells and macrophages are commonly observed in MS lesions. B lymphocytes, plasma cells, and antibodies also contribute to MS pathogenesis. Neutrophils, lymphocytes, monocytes, and platelets, key immune system components, play roles in inflammatory processes, but their association with MS prognosis remains inconclusive. Due to its heterogeneous nature, clinical manifestations of MS vary depending on the location of the affected central nervous system. While several potential biomarkers have been identified for MS diagnosis and monitoring, none have been universally accepted. Studies have examined complete blood count parameters in MS patients, including erythrocyte, platelet, and leukocyte populations. Changes in these parameters have been observed in MS patients compared to healthy controls and may be related to disease prognosis. For example, increased erythrocyte fragility and altered hemoglobin levels have been reported in MS patients. Leukocyte counts and ratios, such as the neutrophil/lymphocyte ratio, have shown associations with disease severity. Platelet activation and interaction with immune cells have also been implicated in MS pathophysiology. Nevertheless, further research is needed to fully understand the role of complete blood count parameters in MS. Identifying reliable biomarkers for early diagnosis and prognosis prediction would greatly enhance MS management. Moreover, these benefits could lead to substantial improvements in achieving complete recovery of patients, surpassing the focus on current symptomatic treatments.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"29 17","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140396844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Warfarin is the most commonly used oral anticoagulant in the treatment and prophylaxis of thromboembolic diseases. In order to prevent thrombosis and to avoid hemorrhagic complications, the patient's INR is kept within a certain range according to the indication and monitored at certain intervals. Our aim in our study is to determine the percentage of patients using warfarin for various indications reaching target INR values. Patients who used warfarin for various indications at our hospital's Internal Medicine outpatient clinic between May 2023 and November 2023 were included in our study, and their INR results were recorded by retrospectively scanning them. A study group was formed with a total of 130 patients. Patients using warfarin due to metallic heart valve replacement, AF, PTE and CVD were evaluated separately according to the target INR value. The percentage of patients with metallic heart valve replacement reaching the target INR value of 2.5-3.5 was calculated as 38.5% (n: 27). The percentages of patients with AF, PTE and CVD reaching their target INR values of 2-3 were calculated as 40% (n:16), 54% (n:7), 70% (n:5), respectively. Considering the entire study group, the percentage of reaching the target INR was calculated as 42% (n: 55). As a result, warfarin not being within the therapeutic range causes serious morbidity and mortality. In our study, the percentage of patients reaching the target INR was found to be 42%. This percentage is very low, and in order to increase this rate, it is necessary to increase patient awareness, increase the frequency of follow-up of patients and develop more effective follow-up strategies.
{"title":"Determination of the Percentage of Patients Using Warfarin to Reach Target INR","authors":"Zekeriya Keskin, M. A. Gedikli","doi":"10.7197/cmj.1415665","DOIUrl":"https://doi.org/10.7197/cmj.1415665","url":null,"abstract":"Warfarin is the most commonly used oral anticoagulant in the treatment and prophylaxis of thromboembolic diseases. In order to prevent thrombosis and to avoid hemorrhagic complications, the patient's INR is kept within a certain range according to the indication and monitored at certain intervals. Our aim in our study is to determine the percentage of patients using warfarin for various indications reaching target INR values. \u0000 Patients who used warfarin for various indications at our hospital's Internal Medicine outpatient clinic between May 2023 and November 2023 were included in our study, and their INR results were recorded by retrospectively scanning them. \u0000 A study group was formed with a total of 130 patients. Patients using warfarin due to metallic heart valve replacement, AF, PTE and CVD were evaluated separately according to the target INR value. The percentage of patients with metallic heart valve replacement reaching the target INR value of 2.5-3.5 was calculated as 38.5% (n: 27). The percentages of patients with AF, PTE and CVD reaching their target INR values of 2-3 were calculated as 40% (n:16), 54% (n:7), 70% (n:5), respectively. Considering the entire study group, the percentage of reaching the target INR was calculated as 42% (n: 55). \u0000 As a result, warfarin not being within the therapeutic range causes serious morbidity and mortality. In our study, the percentage of patients reaching the target INR was found to be 42%. This percentage is very low, and in order to increase this rate, it is necessary to increase patient awareness, increase the frequency of follow-up of patients and develop more effective follow-up strategies.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"13 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140397500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Recep İsmail Akın, Mehmet Atalar, Nisa Bozbiyik, B. Şeker, Gökhan Yılmaz
Objective: To evaluate the contribution of diffusion-weighted imaging (DWI) and measure apparent diffusion coefficient values (ADC) in hepatic hemangiomas. Material and Methods: Seventy patients with liver hemangiomas were evaluated with DWI with a b value of 800 s/mm2. ADC map was created and ADC values were measured for 70 liver masses and normal liver tissue following DWI. ADC measurements of 70 normal liver parenchyma and mean ADC values of 80 hemangiomas are performed. Results: Eighty hemangiomas of 70 patients (50 female and 20 male) were evaluated. The mean age of the patients was 49.61±10.96 years. Hemangiomas were most frequently demonstrated at segment 7 (%28.8), segment 6 (%21.3), and least demonstrated at segment 5 (%5). While the mean ADC measurements of normal livers were 1.06±0.11 x 10-3 mm2/sn, the mean ADC values of hemangiomas were measured as 1.70±0.29 x 10-3 mm2/sn. Conclusion: DWI and the ADC measurements seem to be useful for the diagnosis of liver hemangiomas. DWI should be routinely added to conventional magnetic resonance imaging sequences.
{"title":"Diagnostic contribution of diffusion-weighted imaging in liver hemangiomas","authors":"Recep İsmail Akın, Mehmet Atalar, Nisa Bozbiyik, B. Şeker, Gökhan Yılmaz","doi":"10.7197/cmj.1324648","DOIUrl":"https://doi.org/10.7197/cmj.1324648","url":null,"abstract":"Objective: To evaluate the contribution of diffusion-weighted imaging (DWI) and measure apparent diffusion coefficient values (ADC) in hepatic hemangiomas. \u0000Material and Methods: Seventy patients with liver hemangiomas were evaluated with DWI with a b value of 800 s/mm2. ADC map was created and ADC values were measured for 70 liver masses and normal liver tissue following DWI. ADC measurements of 70 normal liver parenchyma and mean ADC values of 80 hemangiomas are performed. \u0000Results: Eighty hemangiomas of 70 patients (50 female and 20 male) were evaluated. The mean age of the patients was 49.61±10.96 years. Hemangiomas were most frequently demonstrated at segment 7 (%28.8), segment 6 (%21.3), and least demonstrated at segment 5 (%5). While the mean ADC measurements of normal livers were 1.06±0.11 x 10-3 mm2/sn, the mean ADC values of hemangiomas were measured as 1.70±0.29 x 10-3 mm2/sn. \u0000Conclusion: DWI and the ADC measurements seem to be useful for the diagnosis of liver hemangiomas. DWI should be routinely added to conventional magnetic resonance imaging sequences.","PeriodicalId":10750,"journal":{"name":"Cumhuriyet medical journal","volume":"25 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140396852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：