{"title":"EVALUATION OF GENOME SIMILARITIES USING INDEPENDENT COMPONENTS","authors":"T. Sáfadi, L. M. Ferreira","doi":"10.28951/rbb.v38i1.439","DOIUrl":null,"url":null,"abstract":"We propose the use of independent component analysis to find similarities of genomes. Considering different numbers of independent components, the complete linkage method was used to identify groups based on the estimated coefficients of the mixing matrix. The sequences analyzed correspond to the strains of the Mycobacterium tuberculosis genome, ten sequences were analyzed, obtained from the National Center for Biotechnology Information (NCBI, 2017). The GC-content of each sequence was evaluated using a sliding window of 10,000 bases. The clustering analysis using the independent components of the analyzed sequences was essential to verify the dissimilarity of the sequences.","PeriodicalId":36293,"journal":{"name":"Revista Brasileira de Biometria","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Revista Brasileira de Biometria","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.28951/rbb.v38i1.439","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}
引用次数: 0
Abstract
We propose the use of independent component analysis to find similarities of genomes. Considering different numbers of independent components, the complete linkage method was used to identify groups based on the estimated coefficients of the mixing matrix. The sequences analyzed correspond to the strains of the Mycobacterium tuberculosis genome, ten sequences were analyzed, obtained from the National Center for Biotechnology Information (NCBI, 2017). The GC-content of each sequence was evaluated using a sliding window of 10,000 bases. The clustering analysis using the independent components of the analyzed sequences was essential to verify the dissimilarity of the sequences.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
