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CLUSTER ANALYSIS IDENTIFIES VARIABLES RELATED TO PROGNOSIS OF BREAST CANCER DISEASE 聚类分析确定与乳腺癌疾病预后相关的变量
Q4 Medicine Pub Date : 2021-12-23 DOI: 10.28951/rbb.v39i4.596
N. Romeiro, Mara Caroline Torres dos SANTOS, C. Panis, Tiago Viana Flor de SANTANA, Paulo Laerte Natti, D. Rech, Eliandro Rodrigues CIRILO
This work presents a cluster analysis approach aiming to determine distinct groups based on clinicopathological data from patients with breast cancer (BC). For this purpose, the clinical variables were considered: age at diagnosis, weight, height, lymph nodal invasion (LN), tumor-node-metastasis (TNM) staging and body mass index (BMI). Ward's hierarchical clustering algorithm was used to form specific groups. Based on this, BC patients were separated into four groups. The Kruskal-Wallis test was performed to assess the differences among the clusters. The intensity of the influence of variables on the prognosis of BC was also evaluated by calculating the Spearman's correlation. Positive correlations were obtained between weight and BMI, TNM and LN invasion in all analyzes. Negative correlations between BMI and height were obtained in some of the analyzes. Finally, a new correlation was obtained, based on this approach, between weight and TNM, demonstrating that the trophic-adipose status of BC patients can be directly related to disease staging.
这项工作提出了一种聚类分析方法,旨在根据乳腺癌(BC)患者的临床病理数据确定不同的组。为此,我们考虑了临床变量:诊断时的年龄、体重、身高、淋巴结侵袭(LN)、肿瘤-淋巴结-转移(TNM)分期和体重指数(BMI)。采用Ward的分层聚类算法形成特定的分组。在此基础上,将BC患者分为四组。采用Kruskal-Wallis检验来评估聚类之间的差异。还通过计算Spearman相关来评估变量对BC预后的影响程度。在所有分析中,体重与BMI、TNM和LN侵袭均呈正相关。在一些分析中,BMI与身高呈负相关。最后,基于该方法获得了体重与TNM之间的新的相关性,表明BC患者的营养脂肪状态可以直接与疾病分期相关。
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引用次数: 0
UROCHLOA GRASS GROWTH AS A FUNCTION OF NITROGEN AND PHOSPHORUS FERTILIZATION 氮磷施肥对尿草生长的影响
Q4 Medicine Pub Date : 2021-12-03 DOI: 10.28951/rbb.v39i4.487
M. L. D. M. V. Leite, L. Lucena, Raul Caco Alves Bezerra, Mirna Clarissa Rodrigues de Almeida, V. Simões
The urochloa grass (Urochloa mosambicensis) is a perennial grass, C4 plant, with a high photosynthetic rate and CO2 fixation, persistent to water deficit, adapted to a wide diversity of soils and hot climate regions. Thus, the objective was to evaluate the urochloa grass growth and define the best models to estimate plant height as a function of nitrogen and phosphate fertilization. The experimental design was completely randomized, in the 2 x 2 factorial design (presence and absence of nitrogen presence and absence of phosphorus), with four replications. Was used a dose of nitrogen and phosphorus equivalent to 100 kg.ha-1 of N and 150 kg.ha-1 of P2O5, respectively. The following models were used: linear, power, gamma andlogistic to estimate plant height as a function of the following explanatory variables: days after planting, nitrogen and phosphorus doses. The criteria used to determine the best model(s) were as follows: higher adjusted coefficient of determination, lower Akaike information criterion, lower sum of square of residuals and high Willmott index. The plant height in the absence of nitrogen and phosphorus and when applied 100 kg.ha-1 of N and 150 kg.ha-1 of P2O5 was estimated more accurately by the Gamma model with high power of explanation. The adoption of the Gamma model allows to estimate the U.  mosambicensis plant height, in a non-destructive manner, with high precision, speed and low cost, depending of age plant and nitrogen and phosphate fertilization.
尿草(urochloa mosambicensis)是一种多年生草,C4植物,具有高光合速率和二氧化碳固定,持续缺水,适应多种土壤和炎热气候地区。因此,目的是评估尿藻草的生长,并确定最佳模型来估计植物高度作为氮和磷肥的函数。试验设计完全随机化,采用2 × 2因子设计(氮的存在和不存在,磷的存在和不存在),重复4次。使用了相当于100公斤的氮和磷剂量。ha-1 N和150kg。P2O5的ha-1。使用以下模型:线性,功率,伽马和逻辑来估计植物高度作为以下解释变量的函数:种植后天数,氮和磷剂量。确定最佳模型的标准为:较高的调整决定系数、较低的赤池信息准则、较低的残差平方和和较高的Willmott指数。不施氮、磷时株高为100公斤。ha-1 N和150kg。伽玛模型能较准确地估计P2O5的ha-1,具有较高的解释力。采用Gamma模型可以根据植株年龄和氮磷肥施用情况,以非破坏性的方式,高精度、快速和低成本地估算莫桑比索植株高度。
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引用次数: 0
ANALYSIS OF COVID-19 CONTAMINATION AND DEATHS CASES IN BRAZIL ACCORDING TO THE NEWCOMB-BENFORD 根据新库姆-本福德报告分析巴西COVID-19污染和死亡病例
Q4 Medicine Pub Date : 2021-12-03 DOI: 10.28951/rbb.v39i4.535
Carlos Roberto Souza Carmo, F. L. Caneppele, F. C. Nunes
The use of the Newcomb-Benford Law in assessing the quality of health and / orepidemiological information systems can allow relevant decisions to be made to improve these systems. In this context, this research aimed to carry out an assessment of the conformity of theinformation regarding the number of cases of contamination and deaths by COVID-19 in Brazil according to the Newcomb-Benford Law, from the moment of the occurrence of the first case of the disease and from the first death by COVID-19 in the country until the month of September 2020. With the aid of descriptive statistics and the use of metrics related to the Z test and themean absolute deviation it was possible to observe that, both from a national and longitudinal perspective as for the transversal-state perspective, the quantitative data referring to the cases of contamination by the coronavirus and the deaths that occurred as a result of COVID-19 did not present the expected behavior according to the Newcomb-Benford Law. Due to the lack of conformity in relation to the Newcomb-Benford Law, it is suspected that some level of conformity specific to this type of data has occurred, in the Brazilian context, since there are already studies that suggest the existence of proper levels of conformity for certain types of data.
在评估卫生和/或流行病学信息系统的质量时使用纽康姆-本福德法可以做出相关决定,以改进这些系统。在此背景下,本研究旨在根据《纽科姆-本福德法》,评估从巴西出现第一例COVID-19病例和第一例COVID-19死亡病例起至2020年9月,巴西境内COVID-19感染病例和死亡病例数量相关信息的一致性。借助描述性统计和使用与Z检验和平均绝对偏差相关的指标,可以观察到,无论是从国家角度还是纵向角度,还是从横向角度来看,涉及冠状病毒污染病例和因COVID-19而发生的死亡人数的定量数据都没有呈现出根据Newcomb-Benford定律的预期行为。由于缺乏与Newcomb-Benford法律的一致性,在巴西的情况下,由于已经有研究表明某些类型的数据存在适当的一致性水平,因此怀疑这种类型的数据存在某种程度的一致性。
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引用次数: 1
AN APPLICATION OF THE POISSON-WEIBULL MODEL FOR CENSURED DATA 泊松-威布尔模型在精确数据中的应用
Q4 Medicine Pub Date : 2021-12-03 DOI: 10.28951/rbb.v39i4.534
V. Vigas, F. Prataviera, G. O. Silva
In this paper, we proposed the Poisson-Weibull distribution for the modeling of survival data. The motivation to study this model since, in addition to generalizing the Weibull distribution, which is widely used in several areas of knowledge among them the Survival and Reliability analysis, it presents great exibility in the forms of the hazard function. The Poisson-Weibull distribution was created in a composition of discrete and continuous distributions where there is no information about which factor was responsible for the component failure, only the minimum lifetime value among all risks is observed. The maximum likelihood approach was used to estimate the parameters of the model. Also was conducted a simulation study to examine the mean, the bias, and the root of the mean square error of the maximum likelihood estimates of the proposed model according to the censoring percentages and sample sizes. The model selection criteria were also applied, in addition to graphic techniques such as TTT-Plot and Kaplan-Meier. Application to the real data set was used to illustrate the usefulnessof the distribution.
在本文中,我们提出了泊松-威布尔分布的生存数据建模。研究该模型的动机是,除了推广威布尔分布外,它在生存和可靠性分析等几个知识领域中广泛使用,它在风险函数的形式中表现出很大的灵活性。泊松-威布尔分布是在离散和连续分布的组合中创建的,其中没有关于哪个因素导致组件失效的信息,仅观察到所有风险中的最小寿命值。采用极大似然法对模型参数进行估计。还进行了模拟研究,以检验根据审查百分比和样本量提出的模型的最大似然估计的平均值,偏差和均方误差的根。除了TTT-Plot和Kaplan-Meier等图形技术外,还应用了模型选择标准。通过对实际数据集的应用,说明了该分布的有效性。
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引用次数: 0
INCIDENCE AND LETHALITY OF COVID-19 CLUSTERS IN BRAZIL VIA CIRCULAR SCAN METHOD 基于循环扫描方法的巴西COVID-19聚集性发病率和致死率
Q4 Medicine Pub Date : 2021-12-03 DOI: 10.28951/rbb.v39i4.539
Henrique J. P. Alves, F. A. Fernandes, Kelly Pereira de Lima, Ben Dêivide de Oliveira Batista, T. J. Fernandes
The COVID-19 pandemic has spread rapidly around the world in a frightening way. In Brazil, the third country with the highest number of infected and deaths from the disease, it is important for government health authorities to identify the federation units that stand out in cases and deaths from this disease to target resources. The circular scan statistic proposed by Martin Kulldorff allows to identify with some statistical significance the units of the federation that stand out in relation to the number of cases and deaths of COVID-19 in Brazil. Such units of federation are known as clusters. Once these clusters were identified, we used the coefficients of incidence and lethality to better describe the behavior of these clusters during three phases of the pandemic: the initial phase, the peak phase, and also the stability and fall phase. We observed changes in the location of the clusters identified in these three phases and used the R software and also the SaTScan software to obtain the maps and results, which were consistent with what was reported by the Brazilian media.
COVID-19大流行以可怕的方式在全球迅速蔓延。巴西是该病感染和死亡人数第三多的国家,政府卫生当局必须确定在该病病例和死亡人数中突出的联邦单位,以便将资源用于目标。马丁·库多夫(Martin Kulldorff)提出的循环扫描统计数据可以确定联合会在巴西COVID-19病例和死亡人数方面表现突出的单位,并具有一定的统计意义。这样的联邦单位被称为集群。一旦确定了这些聚集性,我们就使用发病率和致死率系数来更好地描述这些聚集性在大流行的三个阶段的行为:初始阶段、高峰阶段以及稳定和下降阶段。我们观察了在这三个阶段确定的群集位置的变化,并使用R软件和SaTScan软件获得了与巴西媒体报道一致的地图和结果。
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引用次数: 0
BEST LINEAR UNBIASED LATENT VALUES PREDICTORS FOR FINITE POPULATION LINEAR MODELS WITH DIFFERENT ERROR SOURCES 具有不同误差源的有限总体线性模型的最佳线性无偏潜在值预测
Q4 Medicine Pub Date : 2021-12-03 DOI: 10.28951/rbb.v39i4.553
Germán Moreno, J. Singer, Edward J. Stanek III
We develop best linear unbiased predictors (BLUP) of the latent values of labeled sample units selected from a finite population when there are two distinct sources of measurement error: endogenous, exogenous or both. Usual target parameters are the population mean, the latent values associated to a labeled unit or the latent value of the unit that will appear in a given position in the sample. We show how both types of measurement errors affect the within unit covariance matrices and indicate how the finite population BLUP may be obtained via standard software packages employed to fit mixed models in situations with either heteroskedastic or homoskedastic exogenous and endogenous measurement errors.
当有两个不同的测量误差来源:内源性、外源性或两者同时存在时,我们开发了从有限总体中选择的标记样本单位的潜在值的最佳线性无偏预测器(BLUP)。通常的目标参数是总体均值,与标记单元相关的潜在值或将出现在样本中给定位置的单元的潜在值。我们展示了两种类型的测量误差如何影响单位内协方差矩阵,并指出如何通过标准软件包获得有限总体BLUP,用于拟合具有异方差或均方差外源和内源测量误差的混合模型。
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引用次数: 0
A CASE STUDY ON ANIMAL BEHAVIOR ANALYSIS USING GAMLSS 利用玻璃进行动物行为分析的案例研究
Q4 Medicine Pub Date : 2021-09-21 DOI: 10.28951/rbb.v39i3.488
Lineu Alberto Cavazani de Freitas, C. Taconeli, J. L. P. D. Silva, P. R. Tamioso, C. Molento
Animal behavior studies usually produce large amounts of data and a wide variety of data structures, including nonlinear relationships, interaction effects, nonconstant variance, correlated measures, overdispersion, and zero inflation, among others. We aimed to explore here the potential of generalized additive models for location, scale and shape (GAMLSS) in analyzing data from animal behavior studies. Data from 20 Romane ewes from two genetic lineages submitted to brushing by a familiar observer were analyzed. Behavioral responses through ear posture changes, a count random variable, and the proportion of time to perform the horizontal ear posture, a continuous random variable on the interval (0,1), with non-null probabilities in zero and one, were analyzed. The Poisson, negative binomial, and their zero-inflated and zero-adjusted extensions models were considered for the count data, whereas the beta distribution and its inflated versions were evaluated for the proportions. Random effects were also included to consider the multilevel structure of the experiment. The zero adjusted negative binomial model has better fitted the count data, whereas the inflated beta distribution performed the best for the proportions. Both models allowed us to properly assess the effects of social separation, brushing, and genetic lineages on sheep behavioral. We may conclude that GAMLSS is a flexible framework to analyze animal behavior data.
动物行为研究通常会产生大量的数据和各种各样的数据结构,包括非线性关系、相互作用效应、非恒定方差、相关测量、过度分散和零膨胀等。我们的目的是在此探讨广义加性模型的位置,规模和形状(GAMLSS)在分析动物行为研究数据的潜力。对来自两个遗传系的20只罗马母羊的数据进行了分析,这些数据由熟悉的观察者提交。分析了通过耳朵姿势变化的行为反应,计数随机变量,以及在区间(0,1)上的连续随机变量,在0和1中具有非零概率,完成水平耳朵姿势的时间比例。计数数据考虑了泊松、负二项及其零膨胀和零调整扩展模型,而比例则评估了beta分布及其膨胀版本。为了考虑实验的多层次结构,还考虑了随机效应。零调整负二项模型较好地拟合了计数数据,而膨胀beta分布对比例的拟合效果最好。这两种模型都使我们能够正确地评估社会分离、刷毛和遗传谱系对绵羊行为的影响。我们可以得出结论,GAMLSS是一个灵活的框架来分析动物行为数据。
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引用次数: 0
Análise de sobrevivência aplicada ao tempo de permanência em planos de saúde. 生存分析应用于健康计划的停留时间。
Q4 Medicine Pub Date : 2021-09-21 DOI: 10.28951/rbb.v39i3.474
Carolina Aparecida Silva de Lima, Luiz Carlos V. Severo Junior, M. Sá
Apesar dos lucros auferidos no segmento de saúde suplementar, o número de segurados vinculados a ele oscilou entre 2015 e 2018, em contraste com o comportamento apresentado entre 2000 e 2014, quando só cresceu. Para compreender parte desse fluxo, isto é, a saída dos segurados desse mercado, objetiva-se analisar o tempo de permanência do segurado em planos de saúde, a partir de dados compostos por 122.381 segurados (e ex-segurados) acompanhados entre os anos de 1984 e 2018. Utilizando-se da análise de sobrevivência tradicional, por meio do estimador de Kaplan-Meier e de modelos paramétricos e semiparamétricos, destacam-se os seguintes resultados: a) a mediana do tempo de permanência no plano é de 4,62 anos; b) a massa de seguradoras é composta (ao longo dos anos observados) predominantemente por mulheres, solteiras, jovens, titulares e aderentes ao contrato de individual/familiar; c) conforme o modelo de Cox selecionado, ser homem (em relação à mulher), ser jovem (em relação ao adulto), ser dependente (em relação ao titular) e ser casado (em relação ao amasiado) aumentam o risco de saída da operadora analisada. Espera-se que esses resultados auxiliem a operadora analisada a (re)direcionar suas políticas comerciais e de subscrição de riscos.
尽管在补充医疗领域获得了利润,但与补充医疗相关的投保人数量在2015年至2018年期间波动,这与2000年至2014年期间的行为形成了对比,当时它只是在增长。为了了解这一流动的一部分,即被保险人退出这一市场,我们的目标是根据1984年至2018年期间122381名被保险人(和前被保险人)的数据,分析被保险人在健康计划中的停留时间。使用传统的生存分析,通过Kaplan-Meier估计和参数和半参数模型,我们强调以下结果:a)在计划中停留时间的中位数为4.62年;b)在计划中停留时间的中位数为4.62年b)保险公司的数量(在观察的年份内)主要由妇女、单身、青年、个人/家庭合同的持有人和成员组成;c)根据Cox所选择的模型,男性(相对于女性)、年轻(相对于成人)、依赖他人(相对于持有者)和已婚(相对于混合)会增加分析运营商的退出风险。预计这些结果将帮助被分析的运营商(重新)指导其商业政策和承保风险。
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引用次数: 1
Comparações entre métodos de desvio padrões aleatórios em experimentos fatoriais com dois níveis por fator e sem repetição. 随机标准偏差方法在因子实验中的比较,每个因子有两个水平,没有重复。
Q4 Medicine Pub Date : 2021-09-21 DOI: 10.28951/rbb.v39i3.485
J. V. Gomes, J. R. Júnior, C. R. G. Dias
Para obter a estimativa da variância aleatória em experimentos fatoriais completos e fracionados com dois níveis por fator avaliados sem repetições, Hamada e Balakrishnan (1998) fornecem uma lista de vários métodos. Assim, com base nessa revisão, o objetivo do presente trabalho consistiu em comparar as estimativas dos desvios-padrão com apenas influências das causas aleatórias de acordo com quatro métodos: de Lenth (1989), de Juan e Pena (1992), de Dong (1993) e sem nenhuma restrição aos dados, aqui denominado de desvio-padrão total. Para isso, foi simulada uma variável aleatória normal com 10.000 valores, cuja simulação foi repetida 16 vezes. Posteriormente, foram substituídos em cada um dos 16 conjuntos de dados, 0%, 1%, 2%, 3% e 4% dos valores aleatórios por outliers com o objetivo de quebrar a aleatoriedade da variável simulada. Com base na estimativa do erro percentual médio absoluto (EPMA) obtida em relação ao desvio-padrão aleatório paramétrico, concluiu-se, por meio da análise de regressão, que ela aumentou em função do aumento do percentual de substituição dos valores aleatórios por outliers, com exceção à obtida de acordo com o método de Juan e Pena (1992). Mesmo assim, para conjuntos de dados com até 3,68% de outliers, os melhores métodos de estimação do desvio-padrão aleatório (Saleatório) foram os de Lenth (1989) e de Dong (1993), por terem fornecido as menores estimativas do EPMA. Acima desse percentual e até 4% de outliers, o método de Juan e Pena (1992) mostrou-se ser melhor. No entanto, como a maior estimativa do EPMA proporcionada pelos três métodos de estimação foi muito baixa (4,00%), e ainda, como as diferenças observadas entre eles foram, praticamente, desprezíveis, concluiu-se que os três métodos forneceram boas estimativas do Saleatório e que, consequentemente, podem ser recomendados para estimar o quadrado médio do resíduo em experimentos fatoriais completos e fracionados com dois níveis por fator e com observações individuais por tratamento. Por outro lado, o método do desvio-padrão total não conseguiu evitar o efeito da não aleatoriedade sobre a estimativa do Saleatório.
Hamada和Balakrishnan(1998)提供了几种方法的列表,以估计完全和分数因子实验的随机方差,每个因子评估两个水平而不重复。旅游评论,然后在此基础上,本工作的目标是将标准差的估计与随机影响因素根据四种方法:Lenth(1989),(1992),胡安和太可惜了东(1993年数据),没有任何限制,这称为总体标准差。为此,我们模拟了一个10,000个值的正态随机变量,模拟重复16次。随后,在16个数据集中,随机值的0%、1%、2%、3%和4%被异常值替换,以打破模拟变量的随机性。根据估计的平均绝对百分比误差标准差方面(EPMA)获得随机参数,结果发现,通过回归分析,她的基础上增加的替代率的随机值的异常值,除了先前的协议与胡安和悲伤(1992)的方法。然而,对于异常值高达3.68%的数据集,估计随机标准偏差(sale报告)的最佳方法是Lenth(1989)和Dong(1993),因为它们提供了最低的EPMA估计。超过这个百分比和4%的异常值,Juan和Pena(1992)的方法被证明是更好的。然而,最大的估计EPMA宠物所提供的三种方法是很低(00%),然而,他们之间的差异,实际上的,结果发现,三种方法提供了很好的Saleatório估计,因此可以被推荐用于估计的均方和残渣完全析因实验可分两个层次的因素和个别观察治疗。另一方面,总标准差法不能避免非随机性对估计的影响。
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引用次数: 1
NONLINEAR MODELS BASED ON QUANTILES IN THE FITTING OF GROWTH CURVES OF PEPPER GENOTYPES 辣椒基因型生长曲线拟合的非线性分位数模型
Q4 Medicine Pub Date : 2021-09-21 DOI: 10.28951/rbb.v39i3.505
Ana Carolina Ribeiro de Oliveira, P. Cecon, Guilherme Alves Puiatti, M. Guimarães, C. Cruz, F. Finger, M. Nascimento, M. Puiatti, Maurício Silva Lacerda
This study aimed to fit nonlinear regression models to model the growth of the characters fruit length (FL) and fruit width (FW) of pepper genotypes (Capsicum annuum L.) over time using the method of ordinary least squares (OLS); and identify the model with the best fit and compare it to the model obtained via nonlinear quantile regression (QR) in the 0.25, 0.5, and 0.75 quantiles. Three regression models (Logistic, Gompertz, and von Bertalanffy) and four fit quality evaluators were adopted: Akaike information criterion, residual mean absolute deviation, and parametric and intrinsic curvature measurements. Five commercial genotypes of pepper were evaluated. Characters FL and FW were evaluated weekly from seven days after flowering, totaling ten measurements. In the estimation by OLS, the Logistic and von Bertalanffy models were considered adequate according to the quality evaluators. In the comparison between the models above by OLS and QR, the superiority of models obtained by QR was verified for the character FL. For the character FW, QR was efficient in three out of the five genotypes, being a valuable alternative in the study of fruit growth.
本研究拟合非线性回归模型,利用普通最小二乘法(OLS)对辣椒基因型(Capsicum annuum L.)果实长度(FL)和果实宽度(FW)随时间的变化进行建模;识别最适合的模型,并将其与非线性分位数回归(QR)在0.25、0.5和0.75分位数上得到的模型进行比较。采用Logistic、Gompertz和von Bertalanffy三种回归模型和四种拟合质量评价指标:Akaike信息准则、残差平均绝对偏差、参数曲率和内在曲率测量。对辣椒的5个商业基因型进行了评价。从开花后第7天开始,每周测定10个测定值。在OLS估计中,质量评价者认为Logistic和von Bertalanffy模型是适当的。通过OLS模型与QR模型的比较,验证了QR模型在FL性状上的优越性。对于FW性状,QR模型在5个基因型中有3个是有效的,在果实生长研究中具有重要的替代价值。
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引用次数: 2
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Revista Brasileira de Biometria
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