Graphene Oxide for Biomedical Applications

K. Santhoshkumar, Monami Das Modak, P. Paik
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引用次数: 31

Abstract

Graphene oxide (GO) is one of the most promising functional materials used in various applications like energy storage (batteries and supercapacitors) sensors, photocatalysis, electronics and in biomedicine. The last 10 years literature on GO for biomedical applications revealed and confirmed the scope of its potential capabilities as biomaterial. GO alone and its modified form with different materials (surface functionalization, immobilization of nanoparticles and composite formation) also proved as a multifunctional candidate for medical biotechnology. A material for its use in biomedical applications must be biocompatible and nontoxic to the living cells.. Although there are some concerns about the toxicity of the GO in specific cases, a dosage range and size effects reported in the literature to use it as a nontoxic materials. In view of all these points, an effort has been made to review and emphasize the scope of GO as a biomedical agent for the applications like targeted drug delivery, cancer theranostics, bioimaging and biosensors etc. Further, potential applications along with the future scope and limitations of GO have also been highlighted in this review.
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生物医学应用的氧化石墨烯
氧化石墨烯(GO)是最有前途的功能材料之一,用于各种应用,如储能(电池和超级电容器)、传感器、光催化、电子和生物医学。过去10年关于氧化石墨烯生物医学应用的文献揭示并证实了其作为生物材料的潜在能力范围。氧化石墨烯本身及其与不同材料的修饰形式(表面功能化,纳米颗粒的固定化和复合形成)也被证明是医学生物技术的多功能候选材料。用于生物医学应用的材料必须具有生物相容性和对活细胞无毒。虽然在特定情况下对氧化石墨烯的毒性存在一些担忧,但文献中报道的剂量范围和大小影响将其用作无毒材料。有鉴于此,本文综述并强调氧化石墨烯作为生物医学试剂在靶向给药、癌症治疗、生物成像和生物传感器等方面的应用范围。此外,本综述还强调了氧化石墨烯的潜在应用以及未来的范围和局限性。
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