Prevalence of asymptomatic SARS-CoV-2 infection in an Austrian cohort.

Clinical Immunology Communications Pub Date : 2021-12-01 Epub Date: 2021-10-07 DOI:10.1016/j.clicom.2021.08.002
Elisabeth Mara, Verena Breitsching, Tanja Schuster, Thomas Pekar
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Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) first emerged at the end of 2019, causing the coronavirus disease (COVID-19). The main sources of infections are infected and asymptomatic persons. One major problem of the pandemic are the diverse symptoms and the varying manifestations of the illness. In this study, the IgG level recognizing the RBD of SARS-CoV-2 was determined within 336 volunteers from the environment of the University of Applied Sciences Wiener Neustadt. The aims of this study were to identify the estimated number of undiscovered COVID-19 infections and the corresponding antibody levels. In total, 11.3% of the nonvaccinated probands had a positive IgG antibody titer against SARS-CoV-2, whereas 4.0% did not test positive for SARS-CoV-2 or had never been tested at the time of sampling. Probands in this study reported tiredness (57,5%), ageusia/anosmia (55%) and headache (47,5%) as most frequent symptoms.

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奥地利队列中无症状 SARS-CoV-2 感染的流行率。
严重急性呼吸系统综合征冠状病毒 2(SARS-CoV-2)于 2019 年底首次出现,引起冠状病毒病(COVID-19)。主要传染源是感染者和无症状者。该流行病的一个主要问题是症状多样,表现各异。本研究测定了维也纳诺伊施塔特应用科学大学 336 名志愿者体内识别 SARS-CoV-2 RBD 的 IgG 水平。这项研究的目的是确定未被发现的 COVID-19 感染者的估计人数以及相应的抗体水平。在未接种疫苗的受试者中,共有 11.3% 的人对 SARS-CoV-2 IgG 抗体滴度呈阳性,而 4.0% 的人在采样时未对 SARS-CoV-2 检测呈阳性或从未接受过检测。在这项研究中,最常见的症状是疲倦(57.5%)、苍老/乏力(55%)和头痛(47.5%)。
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