Incompatibility of Paracetamol with Pediatric Suspensions Containing Amoxicillin, Azithromycin and Cefuroxime Axetil

H. Maswadeh
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引用次数: 4

Abstract

The main objective of this work was to use the Differential Scanning Calorimetry (DSC) and FTIR spectroscopy to study the possible drug-drug or drug-excipient (s) interaction in case of concomitant oral administration of paracetamol with the most common used antibiotics for children. Amoxicillin, azithromycin, cefuroxime axetil and their commercially available suspensions, Amoxil®, Azithromax® and Zinnat® were used. DSC curves for paracetamol, pure antibiotics, commercially available antibiotics and all binary mixtures used in this study showed drug-drug or drug-excipient (s) physical interaction and indicated a possible chemical interaction. To confirm chemical drug-drug or drug-excipient (s) interaction additional ATR-IR spectra for all samples used in this study were obtained. Results obtained from ATR-IR spectra showed drug-excipient (s) interaction in Zinnat®, Azithromax® and binary mixture Azithromax®-paracetamol, while chemical drug-drug interaction was not observed. From this study it can be concluded that the concomitant oral administration of paracetamol with commercially available antibiotics used in this study is not recommended and duration of two hours between the oral administrations of these drugs is strongly recommended to avoid drug-drug or drug-excipient (s) interaction.
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对乙酰氨基酚与含有阿莫西林、阿奇霉素和头孢呋辛酯的儿童混悬液的不相容性
本研究的主要目的是利用差示扫描量热法(DSC)和傅里叶红外光谱(FTIR)研究在儿童最常用的抗生素同时口服扑热息痛时可能的药物-药物或药物-赋形剂相互作用。使用阿莫西林、阿奇霉素、头孢呋辛酯及其市售混悬液、阿莫西林®、阿奇乐美®和Zinnat®。本研究中使用的扑热息痛、纯抗生素、市售抗生素和所有二元混合物的DSC曲线显示了药物-药物或药物-赋形剂的物理相互作用,并表明可能存在化学相互作用。为了确认化学药物-药物或药物-赋形剂的相互作用,本研究中使用的所有样品都获得了额外的ATR-IR光谱。ATR-IR光谱分析结果表明,Zinnat®、阿奇舒美®和阿奇舒美®-扑热息痛二元混合物中存在药物-赋形剂相互作用,但未观察到化学相互作用。从这项研究中可以得出结论,不建议将扑热息痛与本研究中使用的市售抗生素同时口服,并且强烈建议将这些药物的口服间隔为两小时,以避免药物或药物-辅料相互作用。
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