Influence factors of nucleoplasmic bridge frequencies in the peripheral blood lymphocytes of radiation workers

Q4 Medicine 中华放射医学与防护杂志 Pub Date : 2020-02-25 DOI:10.3760/CMA.J.ISSN.0254-5098.2020.02.004

Xue-Lei Tian, X. Lu, Jiang-bin Feng, Yumin Lyu, Mei Tian, Qing-Jie Liu

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引用次数: 1

Abstract

Objective To study the effects of sex, age, length of service, type of work and annual effective radiation dose on nucleoplasmic bridge (NPB) in the peripheral blood lymphocytes of radiation workers. Methods The peripheral blood samples of 100 radiation workers in Henan province were collected and the NPB in peripheral blood lymphocytes were measured by CBMN assay. The frequencies of NPB formation and NPB-containing cells were calculated, and the effects of various factors on NPB incidence were analyzed statistically. Results The NPB frequency in radiation workers was higher than that in healthy people (Z=-8.123, P<0.01). Except for sex, the factors of age, length of service, type of work and annual effective dose had significant influences on NPB (χ2= 7.202-45.571, P<0.05). Conclusions NPB reflects the effect of low-dose long-term chronic irradiation on the occupational radiation workers. Key words: Nucleoplasmic bridges; Radiation worker; Influence factors; Ionizing radiation

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辐射工人外周血淋巴细胞核质桥频率的影响因素

目的探讨性别、年龄、工龄、工种和年有效辐射剂量对辐射工作人员外周血淋巴细胞核质桥(NPB)的影响。方法采集河南省100名放射工作人员外周血标本，采用CBMN法测定外周血淋巴细胞NPB含量。计算NPB形成频率和含NPB细胞频率，统计分析各因素对NPB发生的影响。结果放射工作人员NPB频次高于正常人群(Z=-8.123, P<0.01)。除性别外，年龄、工龄、工种、年有效剂量等因素对NPB有显著影响(χ2= 7.202 ~ 45.571, P<0.05)。结论NPB反映了低剂量长期慢性照射对职业辐射工作者的影响。关键词:核质桥;辐射工作人员;影响因素;电离辐射

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