C. Musetti, S. Bianco, A. Krapcho, M. Palumbo, C. Sissi
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引用次数: 0
Abstract
RNA G-quadruplexes have been recently proposed as physiologically relevant structures in cellular processes which suggests they represent attractive novel drug targets. Up-to-date, limited information of their interactions with small molecules is available. In particular, no systematic comparative analysis of the DNA vs RNA recognition processes has been performed. Here, we investigated the RNA G-quadruplex binding properties of a phenanthroline-based metal complex, (P115)Ni(II), known to efficiently recognize the DNA telomeric sequence. We showed that one ligand molecule can be sandwiched between two RNA G-quadruplex units. Conversely, this binding mode is not occurring using the DNA counterpart as the target sequence
RNA g -四联体最近被认为是细胞过程中的生理相关结构，这表明它们代表了有吸引力的新型药物靶点。它们与小分子相互作用的最新有限信息是可用的。特别是，没有对DNA和RNA识别过程进行系统的比较分析。在这里，我们研究了一种以菲罗啉为基础的金属配合物(P115)Ni(II)的RNA g -四重体结合特性，已知它能有效识别DNA端粒序列。我们发现一个配体分子可以夹在两个RNA g -四重体单元之间。相反，使用DNA对应物作为目标序列时，这种结合模式不会发生
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