Targeting oxidative stress and inflammation in NSAIDs induced gastropathy: A plausible therapeutic approach

Abstract

Deregulation in prostaglandin (PG) biosynthesis, oxidative stress, inflammation, and apoptosis play a major role in the pathogenesis of nonsteroidal anti-inflammatory drug (NSAID)-induced gastropathy. Although the underlying molecular mechanisms involved in this pathophysiological condition is not fully understood, considerable progress has been made in recent years. Also, substantial progress has been made in the search for safe and cost effective gastroprotective agents against NSAID-induced gastropathy. In this article, we briefly describe the contemporary advancement in the field of NSAID-induced gastropathy research and would like to provide a concise view focusing the underlying role of oxidative stress and inflammation in this pathophysiology. Simultaneously, the recent trends in the pursuit of gastroprotective agent have also been highlighted purposely.