The “original antigenic sin” and its relevance for SARS-CoV-2 (COVID-19) vaccination

Clinical Immunology Communications Pub Date : 2021-12-01 DOI:10.1016/j.clicom.2021.10.001

Ger T. Rijkers , Frans J. van Overveld

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引用次数: 15

Abstract

Imprinting of the specific molecular image of a given protein antigen into immunological memory is one of the hallmarks of immunity. A later contact with a related, but different antigen should not trigger the memory response (because the produced antibodies would not be effective). The preferential expansion of cross-reactive antibodies, or T-lymphocytes for that matter, by a related antigen has been termed the original antigenic sin and was first described by Thomas Francis Jr. in 1960. The phenomenon was initially described for influenza virus, but also has been found for dengue and rotavirus. The antibody dependent enhancement observed in feline coronavirus vaccination also may be related to the original antigenic sin. For a full interpretation of the effectivity of the immune response against SARS-CoV-2, as well as for the success of vaccination, the role of existing immunological memory against circulating corona viruses is reviewed and analyzed.

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“原始抗原原罪”及其与COVID-19疫苗接种的相关性

将特定蛋白抗原的分子图像印入免疫记忆是免疫的标志之一。后来与相关的，但不同的抗原接触不应该触发记忆反应(因为产生的抗体不会有效)。交叉反应抗体或t淋巴细胞在相关抗原作用下的优先扩张被称为原始抗原原罪，并由小托马斯·弗朗西斯(Thomas Francis Jr.)于1960年首次描述。这种现象最初被描述为流感病毒，但也发现了登革热和轮状病毒。在猫冠状病毒疫苗接种中观察到的抗体依赖性增强也可能与原始抗原有关。为了全面解释针对SARS-CoV-2的免疫反应的有效性，以及疫苗接种的成功，本文回顾和分析了针对循环冠状病毒的现有免疫记忆的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinical Immunology Communications

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