In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria

Abstract

Article Type Original Research Authors Hussain Yahaya Ungo-kore, MSc1* Joseph Olorunmola Ehinmidu, MSc2 Josiah Ademola Onaolapo, MSc2 Olayeni Stephen Olonitola, MSc3 How to cite this article Yahaya Ungo-kore H., Olorunmola Ehinmidu J., Ademola Onaolapo J., Stephen Olonitola O. In Vitro Antifungal Susceptibility Profiles of Dermatophytes Isolates from Tinea Capitis in Northwest, Nigeria. Infection Epidemiology and Microbiology. 2021;7(3): 347-356 1Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Usmanu Danfodiyo University. 2Department of Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria 3Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna * Correspondence Address: Department of Microbiology, Faculty of Life Sciences, Ahmadu Bello University, Zaria, Kaduna 1044, Nigeria hussaini.yahaya@udusok.edu.ng Article History Received: March 05 2021 Accepted: April 25 ,2021 Published: November 05 ,2021 Background: The fungal infection of tinea capitis is a common mycosis that affects the scalp superficially, especially in children. Oral treatment of this infection remains the preferred treatment process in clinical dermatology. Many antifungals available for dermatophyte treatment lead to treatment failure. Determination of antifungal susceptibility of dermatophytes in-vitro has been reported to be important to curb dermatophyte infections using effective antifungal drugs. The aim of this study was to investigate and determine in vitro minimum inhibitory concentration (MIC) of amphotericin B, ketoconazole, griseofulvin, terbinafine, and fluconazole against dermatophyte clinical isolates using agar dilution method. Materials and Methods: In this study, in vitro susceptibilities of 32 dermatophyte clinical isolates collected from primary school pupils in Sokoto metropolis were investigated to five antifungals (fluconazole, terbinafine, ketoconzole, amphotericin B, and griseofulvin) using the CLSI agar dilution method. Findings: The results obtained revealed that griseofulvin and terbinafine were the most potent antifungal agents among those tested. Conclusion: Agar dilution method could be an alternative method for MIC-determination of antifungal drugs against dermatophyte species, since it is cost effective and affordable with consistent results, especially in developing countries. Copyright© 2021, TMU Press. This open-access article is published under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License which permits Share (copy and redistribute the material in any medium or format) and Adapt (remix, transform, and build upon the material) under the Attribution-NonCommercial terms. 10.52547/iem.7.4.347