Role of Probiotic as an Add-on Therapy in Eradicating Helicobacter Pylori Infection

Abstract

Background: To compare the Helicobacter pylori eradication rate with and without use of Probiotic in conjunction with standard triple regimen. Methods: The patients with symptomatology of Gastritis and Dyspepsia were enrolled for the study. The presence of Helicobacter pylori was confirmed with Urea breath test. The experimental group received probiotic along with triple regimen therapy, while the control group received only triple regimen therapy. After four weeks of completion of treatment, urea breath test was repeated for confirmation of Helicobacter pylori eradication. Patients with negative urea breath test were considered as treatment success. Results: Total 160 patients with Helicobacter pylori infection were enrolled in this study. Patients were divided in two groups i.e. Group-A (Probiotic + triple regimen therapy) and Group-B (Only triple regimen therapy). The mean age of patients in group-A was 35.1±11.2 years and in group-B 37.5±12.9 years. In group-A, H. pylori eradication was seen in 71(88.8%) and 59(73.8%) in group-B with a p-value of 0.015 which is statistically significant. Conclusion: In Helicobacter pylori confirmed Gastritis or Dyspepsia patients, addition of probiotic to standard triple regimen therapy improve eradication rate of H. pylori infection.