The effect of fluoride and arsenic pollution on bone metabolism in exposed population

Q3 Medicine 中华地方病学杂志 Pub Date : 2011-07-20 DOI:10.3760/CMA.J.ISSN.1000-4955.2011.04.011

Q. Zeng, Yun Liu, A. Zhang, F. Hong, N. Ya, Xian Yu

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引用次数: 1

Abstract

Objective To explore the effect of fluoride and arsenic pollution on bone metabolism in exposed population. Methods One hundred and fifty-two fluoride and arsenic exposed people were selected from Jiaole village, Yuzhang town, Xingron county, Guizhou province in 2006, and 59 not exposed people from Daguoduo village 13 km away from Jiaole village were selected as control. Urinary fluorine(UF), urinary arsenic (UAs), urinary hydroxyproline (UHYP), cross-linked N-telopeptides of type I collagen (UNTX) and bone strength index(STI) were detected. Results The main effect of fluoride on UHYP and UNTX were statistically significant (F = 9.785, 4.225, P 0.05). The main effect of arsenic on UNTX was statistically significant (F = 2.660, P 0.05). The interaction between fluoride and arsenic on UNTX was statistically significant (F= 2.429, P 0.05). Conclusions Fluoride exposure can affect the metabolism of collagen and bone resorption, and Arsenic exposure main affect bone resorption, fluoride and arsenic co-exposure have more significant effect on bone resorption. UNTX may be used as biological biomarker of bone metabolism for population co-exposed to fluoride and arsenic in health monitoring. Key words: Fluorine; Arsenic; Enviromnental exposure; Bones

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氟、砷污染对暴露人群骨代谢的影响

目的探讨氟、砷污染对暴露人群骨代谢的影响。方法选取2006年贵州省兴隆县渔张镇胶乐村氟砷暴露人群152人，选取距胶乐村13 km的大郭多村未暴露人群59人作为对照。检测尿氟(UF)、尿砷(UAs)、尿羟脯氨酸(UHYP)、I型胶原交联n端肽(UNTX)和骨强度指数(STI)。结果氟对UHYP和UNTX的主要影响有统计学意义(F = 9.785、4.225,P 0.05)。砷对UNTX的主要影响有统计学意义(F = 2.660, p0.05)。氟与砷对UNTX的交互作用有统计学意义(F= 2.429, P 0.05)。结论氟暴露可影响胶原代谢和骨吸收，其中砷暴露主要影响骨吸收，氟与砷共暴露对骨吸收的影响更为显著。UNTX可作为氟砷共暴露人群骨代谢的生物标志物，用于健康监测。关键词:氟;砷;Enviromnental暴露;骨头

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来源期刊

中华地方病学杂志我国对人类健康危害特别严重的地方性疾病：克山病、大骨节病、碘缺乏病、地方性氟中毒、地方性砷中毒、鼠疫、布鲁氏菌病、寄生虫、新冠肺炎等疾病，同时还报道多发性自然疫源性疾病。

CiteScore

1.60

自引率

0.00%

发文量

8714

期刊介绍： The Chinese Journal of Endemiology covers predominantly endemic diseases threatening health of the people in the areas affected by the diseases including Keshan disease, Kaschin-Beck Disease, iodine deficiency disorders, endemic fluorosis, endemic arsenism, plague, epidemic hemorrhagic fever, brucellosis, parasite diseases and the diseases related to local natural and socioeconomic conditions; and reports researches in the basic science, etiology, epidemiology, clinical practice, control as well as multidisciplinary studies on the diseases.