Evaluation of Biomarkers and Severity of COVID-19 in A Single Center

D. Yalcin, S. Ignak, I. E. Uluisik, Olida Cecen, M. Sonkaya, Ozlem UNAY-DEMİREL
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Abstract

Objectives: The clinical course of COVID-19 ranges from mild to severe. The predictability of clinical outcomes gains importance in managing the disease. In this retrospective cohort study, we aimed to investigate the relationship between biomarker levels and the clinical severity of COVID-19. Methods: COVID-19 patients (n=618) admitted to a tertiary care hospital in Istanbul, Turkey were classified according to their clinical status using a scoring system designed by WHO. Laboratory parameters such as D-dimer, ferritin, and lymphocyte count levels were evaluated. In order to find out the relation between laboratory biomarkers and the severity of COVID-19, univariable and multivariable logistic regression analyses were used. Results: A positive correlation was found when WHO Score was compared with D-dimer levels (r=.508, p
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单中心评估COVID-19的生物标志物和严重程度
目的:新型冠状病毒肺炎的临床病程由轻到重。临床结果的可预测性在疾病管理中具有重要意义。在这项回顾性队列研究中,我们旨在探讨生物标志物水平与COVID-19临床严重程度之间的关系。方法:采用世卫组织设计的评分系统对土耳其伊斯坦布尔一家三级医院收治的COVID-19患者(n=618)进行临床状况分类。实验室参数,如d -二聚体,铁蛋白,和淋巴细胞计数水平进行评估。为了找出实验室生物标志物与COVID-19严重程度之间的关系,采用单变量和多变量logistic回归分析。结果:WHO评分与d -二聚体水平呈正相关(r=。508页
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