Advanced isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy

Abstract

In the current study, advanced isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR are investigated. Since the middle of 20(th) century isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy has been recognized as a non–destructive, label free, highly sensitive and specific analytical method with many potential useful applications in different fields of biomedical research and in particular gum cancer research and diagnosis. Although many technological improvements have been made to facilitate biomedical applications of this powerful analytical technique, it has not yet properly come into the scientific background of many potential end users. Therefore, to achieve those fundamental objectives an interdisciplinary approach is needed with basic scientists, spectroscopists, biologists and clinicians who must effectively communicate and understand each other’s requirements and challenges. In this review we aim at illustrating some principles of isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy as a useful method to interrogate molecules in specimen by isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti– cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy. Penetrating into basics of molecular vibrations might help us to understand whether, when and how complementary information obtained by isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy could become useful in our research and/or diagnostic activities. isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy allowing to acquire information about the molecular composition and structure of a sample within a micrometric scale in a matter of seconds will be illustrated as well as some limitations will be discussed. How biochemical, structural, and dynamical information about the systems can be obtained by bench top isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy instrumentation will be also presented together with some methods to treat and interpret isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy data and applicative examples. The isotopic labeling for the NMR investigation of challenging DNA/RNA of gum cancer cells and anti–cancer Nano drugs for production of isotope–labeled DNA/RNA in gum cancer cells for NMR spectroscopy is one of the most information–rich and concise way to represent the whole of a cell and, as such, fits all the characteristics for the development of a clinically useful biomarker.