Recent advancement in the method of transdermal drug delivery system: A review

Sudip Halder, Prodipta Chakraborty, D. Pradhan, A. Bagchi
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Abstract

A transdermal patch is a medicated adhesive patch that is applied to the skin and used to deliver a particular amount of medication into the bloodstream through the skin. It aids in the recovery of an injured bodily part. The transdermal drug delivery system (TDDS) provides an alternative safe means of drug delivery to previous intrusive techniques. In the past, topically applied lotions and ointments were the most commonly utilised systems for dermatological issues. The fact that some of these formulations cause systemic side effects indicates that they are absorbed through the skin. All topically applied medication formulations intended to transport the active ingredient into the general circulation are included in the transdermal delivery system. To overcome the skin's formidable barrier to topical medication administration, several substances have been utilised. Because of their unique qualities, such as improved bioavailability, regulated pharmaceutical release, and improved patient compliance, TDDS have recently gained increased attention. The current review focuses on the various advancements in transdermal drug delivery, as well as the various available methods for preparing transdermal patches, characterization and assessment tools for transdermal patch preparation, patents, transdermal compound clinical trials, and drug approved and future applications of transdermal drug delivery systems. As a result, in recent years, the Transdermal Drug Delivery System has received a lot of attention.
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经皮给药系统方法的研究进展
透皮贴片是一种贴在皮肤上的药物贴片,用于通过皮肤将一定量的药物输送到血液中。它有助于身体受伤部位的恢复。透皮给药系统(TDDS)提供了一种替代以往侵入式给药技术的安全方法。在过去,局部应用的乳液和软膏是皮肤问题最常用的系统。事实上,这些配方中的一些会引起全身副作用,这表明它们是通过皮肤吸收的。所有旨在将活性成分输送到全身循环的外用药物制剂都包括在透皮给药系统中。为了克服皮肤对局部药物管理的强大障碍,已经使用了几种物质。由于其独特的特性,如提高生物利用度,调节药物释放,提高患者依从性,TDDS最近获得了越来越多的关注。目前的综述重点是透皮给药的各种进展,以及各种可用的制备透皮贴片的方法,透皮贴片制备的表征和评估工具,专利,透皮化合物临床试验,以及经皮给药系统的药物批准和未来应用。因此,近年来,经皮给药系统受到了广泛的关注。
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