The relationship of hemorheological disorders with the development of endotoxicosis in the rehabilitation period of acute poisoning

Y. S. Goldfarb, A. N. Yelkov, A. V. Badalyan, Mikhail Mikhailovich Potshveriya, E. E. Bitkova
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Abstract

The aim of the study. Obtaining new data on the pathogenesis of endotoxicosis (ET) in the rehabilitation period of acute poisoning by assessing the conjugacy of hemorheology (HR) disorders with the development of ET. Material and methods. To obtain new information about the pathogenesis of acute poisoning in the rehabilitation period in 145 patients with severe acute poisoning with psychopharmacological agents (PFAp) due to the addition of pneumonia, neurotoxicants (NTp) with the development of toxic hypoxic encephalopathy and corrosive substances (CSp) with deep and widespread burns of the mucous membranes of the gastrointestinal tract, a pair correlation analysis of the block structure of the obtained correlation matrix was undertaken, establishing the relationship between the two indicators, as well as a canonical correlation analysis revealing the nature of the statistical relationship between groups of indicators, with the calculation of the canonical correlation coefficient. Results. As a result, statistically significant correlations were established between the indicators HR (viscometric, aggregation and indicators hemostasis) and ET (total and effective albumin concentration, the level of medium molecular weight peptides, the content of leukocytes, lymphocytes, neutrophils and circulating immune complexes detected in the blood, and his integral indicators) (-0.32-0.48 for PFAp, 0.29-0.35 for NTp and 0.28-(-0.51) for CSp), as well as statistically significant values canonical correlation coefficients, which indicated the development of ET due to disorders of HR. Limitations. The study was performed on laboratory data obtained during the examination of patients with acute poisoning, and therefore has no restrictions for the further use of this methodological approach in clinical trials. Conclusion. The obtained data can serve to optimize the treatment of ET in this pathology by targeted therapeutic effects on parameters of HR (on viscosity and hemostasis in PFAp and NTp, and in CSp, in addition, on aggregation).
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急性中毒康复期血液流变学障碍与内毒素中毒发展的关系
研究的目的。通过评估血液流变学(HR)障碍与内毒素中毒(ET)发展的耦合关系,获得急性中毒康复期内毒素中毒(ET)发病机制的新数据。材料和方法目的探讨145例急性急性精神药物中毒(PFAp)合并肺炎、神经毒物(NTp)合并中毒性缺氧性脑病、腐蚀性物质(CSp)合并胃肠道粘膜深部广泛烧伤患者康复期急性中毒的发病机制。对得到的相关矩阵的块结构进行配对相关分析,建立两个指标之间的关系,并进行典型相关分析,揭示指标组之间统计关系的本质,并计算典型相关系数。结果。结果,HR(黏度、聚集和止血指标)与ET(血液中检测到的总白蛋白和有效白蛋白浓度、中等分子量肽水平、白细胞、淋巴细胞、中性粒细胞和循环免疫复合物的含量)与其积分指标(PFAp为-0.32-0.48,NTp为0.29-0.35,CSp为0.28-(-0.51))之间的相关性具有统计学意义。典型相关系数的值具有统计学显著性,表明ET的发展是由HR障碍引起的。的局限性。该研究是根据急性中毒患者检查期间获得的实验室数据进行的,因此在临床试验中进一步使用该方法没有限制。结论。所获得的数据可以通过靶向治疗HR参数(PFAp和NTp的粘度和止血,以及CSp的聚集)来优化该病理ET的治疗。
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