Calyculin E and F, Novel Insecticidal Metabolites, from the Marine Sponge, Discodermia sp.

A. Okada, Keisuke Watanabe, K. Umeda, M. Miyakado
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引用次数: 17

Abstract

Two novel insecticidal metabolites, calyculin E (1) and F (2), which had insecticial activity against the German cockroach and mosquito larvae, were isolated from a Japanese marine sponge, Discodermia sp. By an extensive examination of the NMR spectra, the isolates were elucidated to be stereoisomers of calyculin A (3) and B (4), respectively. The molecular shape of calyculin E in solution was deduced to be in a folded conformation by using NMR parameters such as NOE values and coupling constants in conjunction with NOE-restricted energy minimization and computer-assisted molecular modeling.
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Calyculin E和F,新型杀虫代谢物,来自海绵,Discodermia sp.。
从日本海绵Discodermia sp中分离到两种新型杀虫代谢物calyculin E(1)和F(2),对德国蟑螂和蚊子幼虫均有杀虫活性。经核磁共振谱分析,分离物分别为calyculin a(3)和B(4)的立体异构体。利用核磁共振参数NOE值和偶联常数,结合NOE限制能量最小化和计算机辅助分子模型,推导出溶液中calyculin E的分子形状为折叠构象。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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