{"title":"Iron out KRAS-driven cancer.","authors":"Guang Lei, Boyi Gan","doi":"10.1084/jem.20212166","DOIUrl":null,"url":null,"abstract":"<p><p>How to specifically target oncogenic KRAS-driven cancers while sparing normal tissues remains an unmet need in cancer therapy. In this issue of JEM, Jiang et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210739) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.</p>","PeriodicalId":44510,"journal":{"name":"Welt des Islams","volume":"29 1","pages":""},"PeriodicalIF":0.7000,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8919642/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Welt des Islams","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1084/jem.20212166","RegionNum":2,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/3/9 0:00:00","PubModel":"Epub","JCR":"0","JCRName":"RELIGION","Score":null,"Total":0}
引用次数: 0
Abstract
How to specifically target oncogenic KRAS-driven cancers while sparing normal tissues remains an unmet need in cancer therapy. In this issue of JEM, Jiang et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210739) leveraged KRAS-induced iron addiction in cancer cells to design a clever drug delivery approach to enable selective inhibition of KRAS signaling in mutant KRAS tumors but not in normal tissues, offering a new strategy for treating this largely incurable disease.
期刊介绍：
Die Welt des Islams focuses on the history and culture of the people of Islam from the end of the eighteenth century until present times. Special attention is given to literature from this period. Over the last 40 years, Die Welt des Islams has established itself as a journal unrivalled by any other in its field. Its presence in both the major research libraries of the world and in the private libraries of professors, scholars and students shows this journal to be an easy way of staying on top of your discipline. Boasting a large international circulation, Die Welt des Islams takes care to supply its readers with articles in English, French and German.
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