Evaluation of Hepatoprotective Activity of Aqueous Extract of Nyctanthes Arbortristis Bark against Paracetamol-Induced Liver Damage

Abstract

Herbal drugs aimed to determine the hepatoprotective activity of aqueous extract of Nyctanthes arbortristis bark (AQENA) against paracetamol-induced liver damage (PILD) in rat models. Four groups of rats (n=6) were givens one daily administration of 1gm/kg (negative control), 25mg/kg silymarin (positive control) and AQENA (500mg/kg) for 7 days fallowed by induction of hepatotoxicity using of paracetamol. Various parameters, such as physical parameters, biochemical parameters and microscopic analysis ware used to evaluate the hepatoprotective activity. Results indicate that bark extract would a significant (p<0.05) hepatoprotective activity against inducers. These observations were supported by the histological finding. Conclusions: Findings indicate that AQENA possesses a potent hepatoprotective activity against paracetamol.