Mangrove soil-derived Streptomyces: an important resource of pharmaceutical active natural products

Journal of Holistic Integrative Pharmacy Pub Date : 2022-09-01 DOI:10.1016/S2707-3688(23)00050-X

Xuefeng ZHOU

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引用次数: 1

Abstract

The mangrove soil-derived microbes, especially genus Streptomyces strains, have proven to be a rich source of bioactive secondary metabolites and play a critical role in the development of pharmaceutical researches. To understand the structural diversity and bioactivities of the metabolites from the mangrove soil-derived Streptomyces strains, this review for the first time provides a comprehensive overview of 168 natural products isolated from the mangrove soil-derived Streptomyces strains with their bioactivities, up to the end of 2021. Most of the structural types of these compounds are alkaloids, lactones, xanthones, and quinones. The pharmacological mechanisms of some representative lead compounds are well studied, revealing that they have important medicinal potential. This review provides an important reference for the research status of natural products isolated from mangrove soil-derived genus Streptomyces, and reveals that mangrove soil-derived Streptomyces is an important resource of pharmaceutical molecules.

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红树林土源链霉菌:药用活性天然产物的重要资源

红树林土壤微生物，特别是链霉菌属，已被证明是生物活性次生代谢产物的丰富来源，在药物研究的发展中起着至关重要的作用。为了解红树林土源链霉菌代谢产物的结构多样性和生物活性，本文首次对截至2021年底从红树林土源链霉菌中分离到的168种天然产物及其生物活性进行了综述。这些化合物的结构类型大多是生物碱、内酯、山酮和醌类。一些具有代表性的先导化合物的药理机制已经得到了很好的研究，揭示了它们具有重要的药用潜力。本文综述为红树林土源链霉菌属天然产物的研究现状提供了重要参考，揭示了红树林土源链霉菌是药物分子的重要资源。

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Journal of Holistic Integrative Pharmacy

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