The Effect of Eccentric Resistance Training with and Without Blood Flow Restriction on Serum IL6 and MMP9 Levels in Young Active Men

Mohammad Eslamdoust, F. Ghazalian, M. Gholami, K. Ebrahim, B. Bazgir
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Abstract

Background: It has been assumed that during and after BFR exercises, many blood factors are activated and angiogenesis response is stimulated in the arteries. Objectives: Therefore, the current study aimed to determine the effect of two eccentric resistance training methods with and without blood flow restriction on serum IL6 and MMP9 levels in active young men. Methods: In this quasi-experimental study, 16 healthy men with a mean age of 27.8 ± 2.85 (years), the weight of 79.4 ± 12.4 (kg), and a body mass index of 25.5 ± 3.7 (kg/m2) were randomly assigned to either low-intensity eccentric group with BFR or the high-intensity eccentric without BFR. The high-intensity (70% - 80% maximum voluntary contraction MVC) eccentric exercise without BFR included 3 - 5 cycles of eccentric contraction of the quadriceps muscles, up to exhaustion, whereas low-intensity eccentric exercise executed similar exercise modality at intensity of 20% - 30% MVC with blood flow restriction up to exhaustion. Blood samples were taken from antecubital both before and after the exercise to measure serum IL6 and MMP9 values using the ELISA method. Data were analyzed using paired t-test and analysis of variance with repeated measure test in SPSS version 22. A P value of < 0.05 was defined as statistically significant. Results: High-intensity resistance per se and low-intensity resistance exercise with BFR similarly resulted in a non-significant reduction of IL-6 and elevated levels of MMP-9 serum levels in active young men. Conclusions: Overall, the results indicated that a low-intensity resistance exercise session with restricted blood flow and a high-intensity resistance exercise without blood flow restriction equally did not affect IL6 and MMP9 serum of active young men. Further studies are needed to clarify the exact exercise modality that sufficiently stimulates angiogenesis.
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有和无血流限制的偏心阻力训练对年轻运动男性血清il - 6和MMP9水平的影响
背景:人们一直认为,在BFR运动期间和之后,许多血液因子被激活,动脉血管生成反应被刺激。因此,本研究旨在确定有和无血流限制的两种偏心阻力训练方法对活跃青年男性血清IL6和MMP9水平的影响。方法:将16名平均年龄为27.8±2.85(岁)、体重为79.4±12.4 (kg)、体质指数为25.5±3.7 (kg/m2)的健康男性随机分为伴有BFR的低强度偏心组和不伴有BFR的高强度偏心组。无BFR的高强度(70% - 80%最大自主收缩MVC)偏心运动包括3 - 5个周期的股四头肌偏心收缩,直到精疲力竭,而低强度偏心运动在20% - 30% MVC强度下执行类似的运动模式,血流限制直到精疲力竭。运动前后取肛前血样,采用ELISA法测定血清il - 6和MMP9值。数据分析采用配对t检验,方差分析采用重复测量检验,SPSS版本22。P值< 0.05为有统计学意义。结果:高强度抵抗本身和低强度抵抗运动与BFR相似,导致活跃的年轻男性IL-6的非显著降低和血清MMP-9水平的升高。结论:总体而言,结果表明,低强度限制血流的阻力运动和高强度不限制血流的阻力运动对活跃青年男性的il - 6和MMP9血清没有同样的影响。需要进一步的研究来阐明充分刺激血管生成的确切运动方式。
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