Functional Abnormalities in the Hippocampus and Impaired Hippocampal‐dependent Learning in Mice Lacking the 5HT1A Receptors

Z. Sarnyai, E. Sibille, C. Pavlides, Robert J. Fenster, B. McEwen, M. Toth
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Abstract

KO animals showedimpairments in hippocampal-dependent learning and memory tests, such as the hiddenplatform (spatial) version of the Morris water maze (MWM) and the delayed version ofY-maze. Performance of KO mice was not impaired in non-hippocampal memory taskssuch as the visible platform (non-spatial) version of the MWM, the immediate version ofthe Y-maze, and the spontaneous alternation test of working memory. These resultsdemonstrate that 5HT
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缺乏5HT1A受体的小鼠海马功能异常和海马依赖性学习受损
在Morris水迷宫(MWM)的隐藏平台(空间)版本和y型迷宫的延迟版本中,KO动物在海马依赖的学习和记忆测试中表现出损伤。KO小鼠在非海马记忆任务(如MWM的可见平台(非空间)版本、y型迷宫的即时版本和工作记忆的自发交替测试)中的表现未受到损害。这些结果表明5HT
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A Review of the Neurotrophic and Neuroprotective Properties of ONO-1603: Comparison with Those of Tetrahydroaminoacridine, an Antidementia Drug Effects of Azaindolizindone Derivatives ZSET845 and ZSET1446 on Acetylcholine Release in the Cortex and Learning Impairments in the Rat 7th International Conference AD/PD 2005, Sorrento, Italy, March 9–14, 2005 Symptomatic and Disease Modifying Treatments of Alzheimer's Disease SB-236057-A: a selective 5-HT1B receptor inverse agonist.
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