A CRITICAL REVIEW ON NANOEMULSION: ADVANTAGES, TECHNIQUES AND CHARACTERIZATION

INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH Pub Date : 2022-01-08 DOI:10.31069/japsr.v4i3.2

Mrs. Gunjan Pranav Malode, Sarin A Chauhan, Shivam A. Bartare, Lochana M Malode, J. Manwar, R. Bakal

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引用次数: 4

Abstract

Nanoemulsions have small droplet size and are kinetically stable colloidal systems. These are the thermodynamically stable isotropic system in which two immiscible liquids are mixed to form a single phase by means of appropriate surfactant and cosurfactant. Nanoemulsion droplet sizes fall typically in the range of 20–200 nm and shows narrow size distribution. They have enhanced functional properties in comparison to conventional emulsions. The composition and structure of the nanoemulsions can be controlled for the encapsulation and effective delivery of bioactive lipophilic compounds. Nanoemulsions have potential application in the food industry for the delivery of nutraceuticals, coloring and flavoring agents, and antimicrobials. This review aims to provide consolidated information regarding various formulation and characterization techniques developed for nanoemulsions. Various characterization techniques for nanoemulsions include determination of entrapment efficiency, particle size, polydispersity index, zeta potential as well as characterization through differential scanning calorimetry, Fourier-transform infrared spectroscopy and transmission electron microscopy.

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纳米乳的优点、技术及表征

纳米乳液的液滴尺寸小，具有动力学稳定的胶体体系。这是一种热力学稳定的各向同性体系，其中两种不混溶的液体通过适当的表面活性剂和助表面活性剂混合形成单相。纳米乳液滴尺寸一般在20 ~ 200 nm之间，粒径分布较窄。与传统乳剂相比，它们具有增强的功能特性。纳米乳液的组成和结构可以控制，以包封和有效递送生物活性亲脂化合物。纳米乳液在食品工业中有潜在的应用，用于输送营养药品、着色剂和调味剂以及抗菌剂。这篇综述的目的是提供关于各种配方和表征技术开发纳米乳液的综合信息。纳米乳液的各种表征技术包括捕获效率、粒径、多分散性指数、zeta电位的测定，以及通过差示扫描量热法、傅里叶变换红外光谱和透射电子显微镜进行表征。

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INTERNATIONAL JOURNAL OF APPLIED PHARMACEUTICAL SCIENCES AND RESEARCH

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