Role of Epigenetic Modification in the Intergeneration Transmission of War Trauma.

IF 1.5 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY Indian Journal of Clinical Biochemistry Pub Date : 2024-07-01 Epub Date: 2023-05-12 DOI:10.1007/s12291-023-01136-1
Ayeh Bolouki
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Abstract

War trauma has been linked to changes in the neuroendocrine and immunological systems and increases the risk of physical disorders. Traumatic events during the war may have long-term repercussions on psychological and biological parameters in future generations, implying that traumatic stress may have transgenerational consequences. This article addresses how epigenetic mechanisms, which are a key biological mechanism for dynamic adaptation to environmental stressors, may help explain the long-term and transgenerational consequences of trauma. In war survivors, epigenetic changes in genes mediating the hypothalamus-pituitary-adrenal axis, as well as the immune system, have been reported. These genetic modifications may cause long-term changes in the stress response as well as physical health risks. Also, the finding of biomarkers for diagnosing the possibility of psychiatric illnesses in people exposed to stressful conditions such as war necessitates extensive research. While epigenetic research has the potential to further our understanding of the effects of trauma, the findings must be interpreted with caution because epigenetic molecular mechanisms is only one piece of a complicated puzzle of interwoven biological and environmental components.

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表观遗传修饰在战争创伤代际传递中的作用。
战争创伤与神经内分泌和免疫系统的变化有关,并增加了罹患身体疾病的风险。战争期间的创伤事件可能会对后代的心理和生物参数产生长期影响,这意味着创伤应激可能会产生跨代后果。表观遗传机制是动态适应环境压力的关键生物机制,本文探讨表观遗传机制如何帮助解释创伤的长期和跨代后果。据报道,在战争幸存者中,介导下丘脑-垂体-肾上腺轴以及免疫系统的基因发生了表观遗传变化。这些基因改变可能会导致应激反应的长期变化以及身体健康风险。此外,还需要进行广泛的研究,寻找生物标志物来诊断暴露在战争等压力条件下的人是否可能患有精神疾病。虽然表观遗传学研究有可能进一步加深我们对创伤影响的理解,但必须谨慎解读研究结果,因为表观遗传学分子机制只是由生物和环境因素交织而成的复杂拼图中的一块。
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来源期刊
Indian Journal of Clinical Biochemistry
Indian Journal of Clinical Biochemistry BIOCHEMISTRY & MOLECULAR BIOLOGY-
CiteScore
4.50
自引率
4.80%
发文量
74
期刊介绍: The primary mission of the journal is to promote improvement in the health and well-being of community through the development and practice of clinical biochemistry and dissemination of knowledge and recent advances in this discipline among professionals, diagnostics industry, government and non-government organizations. Indian Journal of Clinical Biochemistry (IJCB) publishes peer reviewed articles that contribute to the existing knowledge in all fields of Clinical biochemistry, either experimental or theoretical, particularly deal with the applications of biochemistry, molecular biology, genetics, biotechnology, and immunology to the diagnosis, treatment, monitoring and prevention of human diseases. The articles published also include those covering the analytical and molecular diagnostic techniques, instrumentation, data processing, quality assurance and accreditation aspects of the clinical investigations in which chemistry has played a major role, or laboratory animal studies with biochemical and clinical relevance.
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