{"title":"HPLC determination of the stability of tretinoin in tretinoin–minoxidil solution","authors":"A Zarghi, M Jenabi, A.J Ebrahimian","doi":"10.1016/S0031-6865(98)00014-4","DOIUrl":null,"url":null,"abstract":"<div><p>A new formulation of topical tretinoin–minoxidil solution was prepared and the chemical stability of tretinoin<span> was studied for 6 months at 4°C. A reversed phase high performance liquid chromatography<span> (HPLC) method was developed for determination of tretinoin using cyanocobalamine as an internal standard. Tretinoin was shown that to be stable for at least 6 months used refrigerated storage conditions.</span></span></p></div>","PeriodicalId":19830,"journal":{"name":"Pharmaceutica acta Helvetiae","volume":"73 3","pages":"Pages 163-165"},"PeriodicalIF":0.0000,"publicationDate":"1998-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0031-6865(98)00014-4","citationCount":"11","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pharmaceutica acta Helvetiae","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0031686598000144","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 11
Abstract
A new formulation of topical tretinoin–minoxidil solution was prepared and the chemical stability of tretinoin was studied for 6 months at 4°C. A reversed phase high performance liquid chromatography (HPLC) method was developed for determination of tretinoin using cyanocobalamine as an internal standard. Tretinoin was shown that to be stable for at least 6 months used refrigerated storage conditions.
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