Analysis of the Vaccine Effect on Infectious Diseases by System Dynamics Model

Chen-mei Zhao, Xun Liang, Hui Zhao
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Abstract

What is the impact of vaccine research and development on the prevention and control of infectious diseases, and what is the path of the impact? In this paper, the vaccination rate and effective rate were introduced into the system dynamics model of infectious diseases, based on the prevention and control of epidemic situation in Hubei. And the simulation experiments were carried out on the prevention and control of vaccination. The study of this paper shows that comprehensive vaccination can reduce the peak scale of the epidemic by a hundred times, and the death toll can also be reduced greatly. The higher the vaccination rate and effective rate of the vaccine, the smaller the scale of the epidemic, and the shorter the duration of the epidemic. The vaccine effective rate less than 50% cannot achieve the effect of epidemic prevention and control, and the epidemic will continue to expand for a period of time in the early stage when the vaccine vaccination rate and effective rate are not high. Therefor there is still no possibility to relieve vigilance. We should continue other prevention and control measures, and strengthen the efforts on the research and development as soon as possible to improve the effectiveness of the vaccine.
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用系统动力学模型分析疫苗对传染病的影响
疫苗研发对传染病防控的影响是什么,影响的路径是什么?本文以湖北省疫情防控为例,将疫苗接种率和有效率引入传染病系统动力学模型。并对疫苗预防控制进行了模拟实验。本文的研究表明,综合接种疫苗可使疫情高峰规模减少百倍,死亡人数也可大大减少。疫苗接种率和有效率越高,疫情规模越小,疫情持续时间越短。疫苗有效率低于50%不能达到疫情防控的效果,在疫苗接种率和有效率不高的前期,疫情还会持续扩大一段时间。因此,仍然不可能放松警惕。继续采取其他防控措施,尽快加大研发力度,提高疫苗的有效性。
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