Yujie Lu, C. Darne, I. Tan, B. Zhu, J. Rasmussen, E. Sevick-Muraca
{"title":"Performance evaluation of fluorescence tomography in a Siemens Inveon multimodality scanner","authors":"Yujie Lu, C. Darne, I. Tan, B. Zhu, J. Rasmussen, E. Sevick-Muraca","doi":"10.1117/12.2057818","DOIUrl":null,"url":null,"abstract":"A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.","PeriodicalId":75242,"journal":{"name":"Translational biophotonics","volume":"47 1","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2014-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational biophotonics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1117/12.2057818","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
Abstract
A tri-modal (PET/CT/Optical) small animal tomographic imaging system was developed by integrating our advanced non-contact intensified CCD (ICCD) frequency-domain fluorescence imaging components into a Siemens Inveon scanner. We performed a performance evaluation of the developed imaging system by using the developed regularization-free high-order radiative-transfer-based reconstruction algorithm and custom solid phantoms. Our results show that frequency-domain photon migration (FDPM) fluorescence tomography can achieve better tomographic images with less artifacts and more precise fluorescent source localization compared to the continuous-wave counterpart. The developed multimodal tomographic imaging system provides a powerful tool for translational biomedical research.
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