A Comprehensive Review on Buccal Drug Delivery System

Abstract

This analysis focuses primarily on the several benefits of the buccal drug delivery system (BDDS) over the traditional and systemic formulation. Bypassing first pass metabolism, it aids in improving bioavailability. The formulation of this medication delivery system maintains contact with the mucosal surface, improving absorption and lengthening the resident time. Although not all medications can be administered with this approach, the majority of medications can. Because the degree of mucoadhesion is a crucial phenomenon for the buccal medication delivery system, bio adhesive polymers play a significant role in this drug delivery method. The paper discusses the advantages and disadvantages of the buccal drug delivery system, the anatomy of the oral mucosa, the mechanism of drug penetration, the use of natural polymers and permeation enhancers in the buccal drug delivery system. This evaluation also addresses currently on the market products used as buccal medication delivery systems and their potential future applications.